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Autori: Gazivoda, Tatjana; Raić-Malić, Silvana; Sabolić, Siniša; Kralj, Marijeta; Pavelić, Krešimir; De Clercq, Erik; Mintas, Mladen
Naslov: The New C-5 Substituted Uracil Derivatives of 4, 5-didehydro-5, 6-dideoxy-L-Ascorbic Acid: Synthesis, Antitumoral and Antiviral Evaluations
Izvornik: Drugs of the Future 2006, 31 (Suppl. A): XIX. International Symposium on Medicinal Chemistry / J. R. Prous (ur.). - Istanbul : Prous Science , 2006. 100.
Skup: XIX. International Symposium on Medicinal Chemistry
Mjesto i datum: Istanbul, Turska, 29.08.-02.09. 2006.
Ključne riječi: L-ascorbic acid; C-5 substituted uracil derivatives; cytostatic activities; antiviral activities
Sažetak:
We have found in our previous studies that some pyrimidine and purine derivatives of 4, 5-didehydro-5, 6-dideoxy-L-ascorbic acid possess pronounced cytostatic activities against some malignant human tumor cell lines [1]. In this connection we have synthesized a series of novel C-5 pyrimidine derivatives of 2, 3-di-O-benzyl-4, 5-didehydro-5, 6-dideoxy-L-ascorbic acid (Figure) by Stille reaction of the 5-iodouracil derivative of L-ascorbic acid with unsaturated stannanes. The novel compunds were evaluated for their cytostatic activities against malignant human tumor cell lines: pancreatic carcinoma, cervical carcinoma, breast carcinoma, laryngeal carcinoma, colon carcinoma, human T-lymphocytes, as well as human fibroblast cells. Inhibitory activity evaluations of those compounds against herpes simplex virus type 1 and 2, vaccinia virus, variccela-zoster virus, vesicular stomatitis virus, Coxsackie virus B4, respiratory syncytial virus, parainfluenza virus, reovirus-1, sindbis virus and Punta Toro virus were also performed. The results of antitumoral and antiviral evaluations will be presented. [1] (a) T. Gazivoda et al, Carbohydrate Res. 2006 (341) 433 ; (b) T. Gazivoda et al, Bioorg. Med. Chem. 2005 (13) 131 ; (c) S. Raić-Malić et al, J. Med. Chem. 2000 (43) 4806 ; (d) S. Raić-Malić et al, J. Med. Chem. 1999 (42) 2673.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0098093
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Farmacija



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