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Pregled bibliografske jedinice broj: 265173

Zbornik radova

Autori: Sikirić, Predrag; Kušec, Rajko; Kalogjera, Livio; Rotkvić, Ivo; Duvnjak, Marko; Petek, Marijan; Suchanek, Ernest; Grabarević, Željko; Miše, Stjepan; Artuković, Branka; Džaja, Petar; Banić, Marko; Brkić, Tomislav; Anić, Branimir; Anić, Tomislav; Uglešić, Miro
Naslov: Bromocriptine andamantadine protect against "naturally occuring" (fracture induced) stress gastric ulcers
( Bromocriptine andamantadine protect against "naturally occuring" (fracture induced) stress gastric ulcers )
Izvornik: Abstracts of the first symposium on experimental ulcer disease and its clinical relevance in: Digestive Disease and SciencesZagreb : Plenum Publishing Corporation , 1990. 1566-1566.
Skup: Symposium on experimental ulcer disease and its clinical relevance (1 ; 1989)
Mjesto i datum: Zagreb, Jugoslavija, 26.-28.11.1989.
Ključne riječi: bromocriptine; amantadine; stress gastric ulcers; rats
( bromocriptine; amantadine; stress gastric ulcers; rats )
Sažetak:
It could be argued that many experimental "stress-ulcersinducing methods are not completely related to the naturally occuring circumstances (e.g.restraint stress). Therefore, the influence of dopamine agents bromocriptine (10.o mg/kg b.w.) and amantadine (20.0 mg/kg b.w.) on fracture (metatarsus)-induced gastric lesions was invastigated in rats (Wistar strain, both sexes, 200 g b.w.) Each drug was given i.p. 1 h before injury induction and subsequently once a day. The control animals received an equivolume of saline. The animals were sacrificed 1, 2, 3, 5, 8, 12 and 33 days after injury induction (15 rats for each experimental group) and the stomach examined for presence of lesions as discrabed before (Sikirić et al. , Eur. J. Pharmacol. 1985, 1986, 1987, 1988). Marked gastric lesions were found in the control rats sacrificed 5 (number of lesions per rat 3.7.+0.3, sum of their longest diameters per rat 4.2+-o.1 mm) and 8 (4.0.+-0.2, 4.3+-0.3 mm) days post fracture. No lesionswere noted in treated groups (Student´s t-test vs controls

Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Veterinarska medicina



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