engleski

Bromocriptine andamantadine protect against "naturally occuring" (fracture induced) stress gastric ulcers

It could be argued that many experimental "stress-ulcersinducing methods are not completely related to the naturally occuring circumstances (e.g.restraint stress). Therefore, the influence of dopamine agents bromocriptine (10.o mg/kg b.w.) and amantadine (20.0 mg/kg b.w.) on fracture (metatarsus)-induced gastric lesions was invastigated in rats (Wistar strain, both sexes, 200 g b.w.) Each drug was given i.p. 1 h before injury induction and subsequently once a day. The control animals received an equivolume of saline. The animals were sacrificed 1, 2, 3, 5, 8, 12 and 33 days after injury induction (15 rats for each experimental group) and the stomach examined for presence of lesions as discrabed before (Sikirić et al. , Eur. J. Pharmacol. 1985, 1986, 1987, 1988). Marked gastric lesions were found in the control rats sacrificed 5 (number of lesions per rat 3.7.+0.3, sum of their longest diameters per rat 4.2+-o.1 mm) and 8 (4.0.+-0.2, 4.3+-0.3 mm) days post fracture. No lesionswere noted in treated groups (Student´s t-test vs controls <P 0.001). Light microscopical examination revealed gastric erosions and no lesions were found in macroscopicallyundamaged mucosa. Therefore, this data indicates that the fracture induced gastric lesions develop in a later period (probably correlating with growing postfracture haematoma) with spontaneous healing within a few days (as non-specific "stres ulcers"). Hence, the fracture-inducedgastric lesions would be a suitable model for further experimental research. On the other hand, the beneficial effect of both bromocriptine and amantadine clearly demonstrated that in addition to the effectiveness on coventional "stress ulcers" models (e.g. Hernandez et al., Life SCI.1984) a strong protection could be achieved also against naturally occuring (fracture-induced) stress ulcers.

bromocriptine ; amantadine ; stress gastric ulcers ; rats

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