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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 270905

Časopis

Autori: Rajić, Zrinka; Zorc, Branka; Raić-Malić, Silvana; Ester, Katja; Kralj, Marijeta; Pavelić, Krešimir; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Naslov: Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations
Izvornik: Molecules (1420-3049) 11 (2006), 11; 837-848
Vrsta rada: članak
Ključne riječi: Hydantoin; L- and D-amino acids; antiviral activity; antitumoral activity
Sažetak:
3, 5-Disubstituted hydantoin (1, 3-imidazolidinedione) derivatives 5a-h were prepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L- and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic and antiviral activities. Among all the compounds evaluated, 3-benzhydryl-5-isopropyl hydantoin (5a) showed a weak but selective inhibitory effect against vaccinia virus (EC50 = 16  g/mL ; selectivity index: 25). 3-Cyclohexyl-5-phenyl hydantoin (5g) showed inhibitory activity against cervical carcinoma (HeLa, IC50 = 5.4  M) and breast carcinoma (MCF-7, IC50 = 2  M), but also cytotoxic effects towards human normal fibroblasts (WI 38). On the contrary, the 3-benzhydryl-5-phenyl substituted hydantoin derivative 5h showed moderate inhibitory activity towards HeLa, MCF-7, pancreatic carcinoma (MiaPaCa-2), lung carcinoma (H 460) and colon carcinoma (SW 620) (IC50 = 20 23  M), but no effect on WI 38.
Projekt / tema: 0006543, 0125003, 0098093
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Farmacija
URL cjelovitog teksta:
Google Scholar: Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations
Napomene:
Stranice navedene u časopisu: NIL_15-NIL_26.



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