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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 273729

Časopis

Autori: Grgurević, Ivica; Vince, Adriana; Buljevac, Mladen; Banić, Marko; Jeren-Strujić, Branka; Kes, Petar; Kujundžić, Milan; Leko, Ninoslav; Lukić, Ivan Krešimir; Slavićek, Jasna
Naslov: Efficacy of interferon-alpha in the treatment of chronic hepatitis C in dialysis patients : two therapeutic protocols compared
( Efficacy of interferon-alpha in the treatment of chronic hepatitis C in dialysis patients : two therapeutic protocols compared )
Izvornik: Nephron. Clinical practice (1660-2110) 103 (2006), 1; C8-C11
Vrsta rada: članak
Ključne riječi: interferon alpha; chronic hepatitis C; dyalisis
( nterferon alpha; chronic hepatitis C; dyalisis )
Sažetak:
Data on the efficacy of particular therapeutic protocols of interferon-alpha (IFN-alpha) treatment for chronic hepatitis C in patients on hemodialysis (HD) vary. AIim was to compare the efficacy of two different therapeutic protocols for HD patients. 15 hepatitis C virus (HCV)-positive patients on chronic HD at two dialysis centers: 8 patients treated with IFN-alpha 3 x 3 MU/week s.c. for 6 months (group A), and 7 patients treated with IFN-alpha 3 x 5 MU/week for 3 months, then 1 x 5 MU/week for another 3 months (group B). End of treatment response (ETR) and sustained virologic response (SVR) were evaluated by HCV-RNA determination. There was no statistically significant difference between the two patient groups according to age, sex, duration of HD and HCV infection. ETR was 87.5% (7/8) in group A and 28.5% (2/7) in group B, being statistically significant (p < 0.05). Although better SVR [50% (4/8) vs. 28.5% (2/7)] and lower drop-out rate [0% (0/8) vs. 28.5% (2/7)] were achieved in group A compared to group B, these differences did not reach statistical significance (p > 0.05). Therapy with IFN-alpha 3 x 3 MU/week s.c. for 6 months seems to be more appropriate for treatment of hepatitis C in HD patients, mostly due to better tolerability, i.e. lower drop-out rate. These differences could be attributed to different pharmacokinetic properties of the particular therapy protocol. 2006 S. Karger AG, Basel
Projekt / tema: 0143001
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.karger.com/Article/FullText/90505
Broj citata:
Altmetric:
DOI: 10.1159/000090505
URL cjelovitog teksta:
Google Scholar: Efficacy of interferon-alpha in the treatment of chronic hepatitis C in dialysis patients : two therapeutic protocols compared



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