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Autori: Restek-Samaržija, Nada; Pizent, Alica; Čorović, Naima; Zavalić, Marija; Milković-Kraus, Sanja
Naslov: DMSA in therapy occupational lead poisoning
( DMSA in therapy occupational lead poisoning )
Izvornik: Knjiga sažetakaZagreb, Hrvatska : Hrvatsko toksikološko društvo , 1996. 92.
Skup: 1. hrvatski toksikološki kongres (s međunarodnim sudjelovanjem) - CROTOX
Mjesto i datum: Zagreb, Hrvatska, 17-19.04.1996.
Ključne riječi: chelation; chronic lead poisoning; dimercaptosuccinic acid (DMSA); occupational exposure
( chelation; chronic lead poisoning; dimercaptosuccinic acid (DMSA); occupational exposure )
Sažetak:
DMSA (2,3-meso dimercaptosuccinic acid) is a new oral chelating agent. Its efficacy was confirmed in the USA, especially in the treatment of children lead poisoning. There are few studies relatedto DMSA chelation in occupationally exposed workers. This study introduces DMSA for the first time in our country with intention to evaluate its efficiency in chronic occupational lead poisoning. Seven workers, employed in a lead battery factory for at least four years, with elevated blood level concentrations (PbB) (>50 ?g/100 ml ) and a positive EDTA lead mobilization test (>600 ?g Pb/24 h urine), were treated with DMSA for 19 days. DMSA was administrated orally in doses of 700 mg DMSA every 8 hours from day 1 to day 5, and 700 mg every 12 hours from day 6 to day 19 of the treatment. Blood lead values declined during the treatment (mean Pb decreased to 15,4% of pretreatment values) with a simultaneous increase in urinary excretion of lead (P<0,01 ). However 15 days after the therapy, PbB values rebounded for 35%, but they did not exceed the treshold level (30 ?g/100 ml). The EDTA lead mobilization test detected a 54% decline of pretreatment values (P<0,01) suggesting a significant reduction of lead in the body. Uor results show that DMSA is an efficient chelating agent for treatment of chronic lead poisonig in occupationally exposed patients.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: 00220301, 00220307
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti



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