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Pregled bibliografske jedinice broj: 277113

Časopis

Autori: Boban Blagaić, Alenka; Blagaić, Vladimir; Mirt, Mirela; Jelovac, Nikola; Dodig, Goran; Ručman, Rudolf; Petek, Marijan; Turković, Branko; Anić, Tomislav; Dubovećak, Miroslav; Starešinić, Mario; Seiwerth, Sven; Sikirić, Predrag
Naslov: Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats
( Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats )
Izvornik: European journal of pharmacology (0014-2999) 512 (2005), 2-3; 173-179
Vrsta rada: članak
Ključne riječi: Serotonin syndrome ; pargyline ; L-tryptophan ; hyperthermia ; hypothermia ; hind limbs abduction ; pentadecapeptide BPC 157 ; rats
( Serotonin syndrome ; pargyline ; L-tryptophan ; hyperthermia ; hypothermia ; hind limbs abduction ; pentadecapeptide BPC 157 ; rats )
Sažetak:
Serotonin syndrome commonly follows irreversible monoamine oxidase (MAO)-inhibition and subsequent serotonin (5-HT) substrate (in rats with fore paw treading, hind limbs abduction, wet dog shake, hypothermia followed by hyperthermia). A stable gastric pentadecapeptide BPC 157 with very safe profile (inflammatory bowel disease clinical phase II, PL-10, PLD-116, PL-14736, Pliva) reduced the duration of immobility to a greater extent than imipramine, and, given peripherally, has region specific influence on brain 5-HT synthesis (alpha-[14C]methyl-L-tryptophan autoradiographic measurements) in rats, different from any other serotonergic drug. Thereby, we investigate this peptide (10 microg, 10 ng, 10 pg/kg i.p.) in (i) full serotonin syndrome in rat combining pargyline (irreversible MAO-inhibition ; 75 mg/kg i.p.) and subsequent L-tryptophan (5-HT precursor ; 100 mg/kg i.p. ; BPC 157 as a co-treatment), or (ii, iii) using pargyline or L-tryptophan given separately, as a serotonin-substrate with (ii) pargyline (BPC 157 as a 15-min posttreatment) or as a potential serotonin syndrome inductor with (iii) L-tryptophan (BPC 157 as a 15 min-pretreatment). In all experiments, gastric pentadecapeptide BPC 157 contrasts with serotonin-syndrome either (i) presentation (i.e., particularly counteracted) or (ii) initiation (i.e., neither a serotonin substrate (counteraction of pargyline), nor an inductor for serotonin syndrome (no influence on L-tryptophan challenge)). Indicatively, severe serotonin syndrome in pargyline + L-tryptophan rats is considerably inhibited even by lower pentadecapeptide BPC 157 doses regimens (particularly disturbances such as hyperthermia and wet dog shake thought to be related to stimulation of 5-HT2A receptors), while the highest pentadecapeptide dose counteracts mild disturbances present in pargyline rats (mild hypothermia, feeble hind limbs abduction). Thereby, in severe serotonin syndrome, gastric pentadecapeptide BPC 157 (alone, no behavioral or temperature effect) has a beneficial activity, which is likely, particular, and mostly related to a rather specific counteraction of 5-HT2A receptors phenomena.
Projekt / tema: 0108116, 0108238, 0108196
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T1J-4FV9MN1-2-C&_cdi=4892&_user=3875467&_orig=search&_coverDate=04%2F11%2F2005&_sk=994879997&view=c&wchp=dGLbVtz-zSkWz&md5=15a0dbb38b72beb9f42b330db41fa632&ie=/sdarticle.pdf
https://www.sciencedirect.com/science/article/pii/S0014299905002086?via%3Dihub
https://doi.org/10.1016/j.ejphar.2005.02.033
Broj citata:
Altmetric:
DOI: 10.1016/j.ejphar.2005.02.033
URL cjelovitog teksta:
Google Scholar: Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats



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