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Pregled bibliografske jedinice broj: 277840

Časopis

Autori: Starešinić, Mario; Petrović, Igor; Novinšćak, Tomislav; Jukić, Ivana; Pevec, Damira; Suknaić, Slaven; Kokić, Neven; Batelja, Lovorka; Brčić, Luka; Boban-Blagaić, Alenka; Zorić, Zdenka; Ivanović, Domagoj; Ajduk, Marko; Sebečić, Božidar; Patrlj, Leonardo; Soša, Tomislav; Buljat, Gojko; Anić, Tomislav; Seiwerth, Sven; Sikirić, Predrag
Naslov: Effective therapy of transected quadriceps muscle in rat : Gastric pentadecapeptide BPC 157
( Effective therapy of transected quadriceps muscle in rat : Gastric pentadecapeptide BPC 157 )
Izvornik: Journal of orthopaedic research (0736-0266) 24 (2006), 5; 1109-1117
Vrsta rada: članak
Ključne riječi: transected quadriceps muscle healing; gastric pentadecapeptide BPC 157; systemic peptide treatment; rats
( transected quadriceps muscle healing; gastric pentadecapeptide BPC 157; systemic peptide treatment; rats )
Sažetak:
We report complete transection of major muscle and the systemic peptide treatment that induces healing of quadriceps muscle promptly and then maintains the healing with functional restoration. Initially, stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419, PL-10, PLD-116, PL 14736 Pliva, Croatia ; in trials for inflammatory bowel disease ; wound treatment ; no toxicity reported ; effective alone without carrier) also superiorly accelerates the healing of transected Achilles tendon. Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat. BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily ; the first application 30 min posttransection, the final 24 h before sacrifice. It consistently improves muscle healing throughout the whole 72-day period. Improved are: (i) biomechanic (load of failure increased) ; (ii) function (walking recovery and extensor postural thrust/motor function index returned toward normal healthy values) ; (iii) microscopy/immunochemistry [i.e., mostly muscle fibers connect muscle segments ; absent gap ; significant desmin positivity for ongoing regeneration of muscle ; larger myofibril diameters on both sides, distal and proximal (normal healthy rat-values reached)] ; (iv) macroscopic presentation (stumps connected ; subsequently, atrophy markedly attenuated ; finally, presentation close to normal noninjured muscle, no postsurgery leg contracture). Thus, posttransection healing-consistently improved-may suggest this peptide therapeutic application in muscle disorders.
Projekt / tema: 0108238, 0108196
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Broj citata:
Altmetric:
DOI: 10.1002/jor.20089
URL cjelovitog teksta:
Google Scholar: Effective therapy of transected quadriceps muscle in rat : Gastric pentadecapeptide BPC 157



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