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Pregled bibliografske jedinice broj: 277909

Časopis

Autori: Miše, Stjepan; Tonkić, Ante; Pešutić-Pisac, Valdi; Tonkić, Marija; Miše, Sandro; Capkun, Vesna; Batelja, Lovorka; Blagaić Boban, Alenka; Kokić, Neven; Zoričić, Ivan; Saifert, Davor; Anić, Tomislav; Seiwerth, Sven; Sikirić, Predrag
Naslov: The presentation and organization of adaptive cytoprotection in the rat stomach, duodenum, and colon
( The presentation and organization of adaptive cytoprotection in the rat stomach, duodenum, and colon )
Izvornik: Medical science monitor (1234-1010) 12 (2006), 4; 146-153
Vrsta rada: članak
Ključne riječi: stomach; duodenum; colon; adaptive cytoprotection; rat
( stomach; duodenum; colon; adaptive cytoprotection; rat )
Sažetak:
Adaptive cytoprotection could be demonstrated in lesion attenuation within the whole gastrointestinal tract, in particular sequences, with onset and duration longer than the initial short-lasting period (i.e. one hour) defined by Robert in the stomach only. MATERIAL/METHODS: Adaptive cytoprotection possibly appeared and lesions were attenuated when the stomach, duodenum or colon, in various combinations and sequences, were challenged with initial (mild) and/or final (strong) irritants over a two-week period. Rats were challenged with the mild or strong irritants 25% or 96% ethanol intragastrically 1 ml/rat (stomach) and cysteamine 40 mg or 400 mg/kg subcutaneously (duodenum), or intrarectally (colon). To postulate the prostaglandin relationship known in Robert's cytoprotection and adaptive cytoprotection, indomethacin (1 mg/kg subcutaneously) was given simultaneously with the second challenge. RESULTS: Administering the mild and strong irritant protocols within the same part of the gastrointestinal tract, adaptive cytoprotection presents in the stomach (1 h to 14 days), duodenum (2 h to 14 days), but not in the colon. With these protocols applied to different parts of the gastrointestinal tract, adaptive cytoprotection cross-reaction was evident in the stomach-duodenum, duodenum-stomach (1 h-14 days and 2 h-14 days), stomach-colon, and duodenum-colon (both 2-24 hours), but not in the colon-stomach or colon-duodenum. This protection was fully antagonized with indomethacin. CONCLUSIONS: As observed for a day and even weeks, stomach-duodenum-colon adaptive cytoprotection is an important new defensive phenomenon.
Projekt / tema: 0108196, 0108238
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: The presentation and organization of adaptive cytoprotection in the rat stomach, duodenum, and colon



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