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Pregled bibliografske jedinice broj: 278001

Časopis

Autori: Bilić, Mario; Bumber, Željko; Boban Blagaić, Alenka; Batelja, Lovorka; Seiwerth, Sven; Sikirić, Predrag
Naslov: The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice
( The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice )
Izvornik: Burns (0305-4179) 31 (2005), 3; 310-315
Vrsta rada: članak
Ključne riječi: Stable gastric pentadecapeptide BPC 157; Cream; Laser injury; Improved healing; Mice
( Stable gastric pentadecapeptide BPC 157; Cream; Laser injury; Improved healing; Mice )
Sažetak:
The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV ; mol. wt. 1419), which is at present in phase II clinical trials for the treatment of inflammatory bowel disease, has been shown to counteract healing impairment by systemic corticosteroids in burned mice, both in vivo and in vitro, in the absence of carrier or protease inhibitor. Because of the particular healing problems associated with laser use, we have now studied the effect of pentadecapeptide BPC 157 on CO2 laser injuries (Sharplan 1075 laser: 20W, distance 12.5cm, spot size 0.8mm and exposure time 1s) created on the dorsal skin of anaesthetised male NMRI– Hannover mice. The injury was either not treated or treated by topical application of a thin layer of neutral cream containing pentadecapeptide BPC 157 (1μ g, 1ng or 1pg (dissolved in saline)/g) or vehicle only, once daily, with the first application 60min after injury and the last 24h before killing (1, 7 and 21 days after the laser application). BPC 157 consistently improved healing after the CO2 laser injury, both macroscopically and microscopically. The effect was produced with a simple method of application and favourable peptide stability (no carrier), and confirms the effectiveness of an ointment containing 1μ g BPC 157 (dissolved in saline)/g neutral cream.
Projekt / tema: 0108196, 0108238
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T52-4F9739B-3-1&_cdi=4990&_user=3875467&_orig=search&_coverDate=05%2F31%2F2005&_sk=999689996&view=c&wchp=dGLbVzb-zSkWW&md5=3ca86d04b737c800a8bb7d2f55acf0a3&ie=/sdarticle.pdf
Broj citata:
Altmetric:
DOI: 10.1016/j.burns.2004.10.013
URL cjelovitog teksta:
Google Scholar: The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice



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