Hrvatska znanstvena bibliografija (CROSBI)



Pregled bibliografske jedinice broj: 281989

Časopis

Autori: Barbarić, Monika; Kralj, Marijeta; Marjanović, Marko; Husnjak, Ivana; Pavelić, Krešimir; Filipović-Grčić, Jelena; Zorc, Davor; Zorc, Branka
Naslov: Synthesis and in vitro antitumor effect of diclofenac and fenoprofen thiolated and nonthiolated polyaspartamide-drug conjugates
Izvornik: European Journal of Medicinal Chemistry (0223-5234) 42 (2007), 1; 20-29
Vrsta rada: članak
Ključne riječi: diclofenac; fenoprofen; polyaspartamide; thiomer; polymer-drug conjugate; human tumor cell lines; antiproliferative effect
Sažetak:
The paper reports the synthesis and the antiproliferative effect of new thiomer-diclofenac and fenoprofen conjugates, hydrophilic, bioadhesive, polymeric prodrugs, as well as antiproliferative effect of diclofenac, fenoprofen and a series of previously described polymer-fenoprofen conjugates on five tumor cell lines. Thiolated and nonthiolated polyaspartamides were chosen as polymeric components. The drug loading ranged from 5.6 to 22.4%, and amount of SH groups from 6.9 to 45.6 mu mol g-1. Tensile studies demonstrated a clear correlation between the thiol amount and mucoadhesive properties of the conjugates. The growth inhibitory activity of the tested polymer-drug conjugates clearly demonstrates that polyaspartamide-type polymers, especially thiolated polymers, enable the inhibition of tumor cells' growth with significantly lower doses of the active substance.
Projekt / tema: 0120002, 0006561, 0098093, 0006543
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Farmacija
URL cjelovitog teksta:
Google Scholar: Synthesis and in vitro antitumor effect of diclofenac and fenoprofen thiolated and nonthiolated polyaspartamide-drug conjugates