Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

CSF levels of total tau protein, phosphorylated tau epitopes 181, 199 and 231 as markers for early-onset Alzheimer's dementia (CROSBI ID 526321)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Boban, Marina ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian ; Šimić, Goran CSF levels of total tau protein, phosphorylated tau epitopes 181, 199 and 231 as markers for early-onset Alzheimer's dementia // European journal of neurology. 2006

Podaci o odgovornosti

Boban, Marina ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian ; Šimić, Goran

engleski

CSF levels of total tau protein, phosphorylated tau epitopes 181, 199 and 231 as markers for early-onset Alzheimer's dementia

Abnormal hyperphosphorylation of the microtubule-associated protein tau and its incorporation into neurofibrillary tangles are major hallmarks of the pathogenesis of Alzheimer's disease (AD). The cerebrospinal fluid (CSF) levels of phosphorylated tau proteins reflect the phosphorylation state of tau in the brain. Using monoclonal antibodies, different tau phosphoepitopes can be sensitively detected in CSF. To determine the diagnostic value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181, 199 and 231 (p-tau-181, p-tau-199, p-tau-231) in early onset Alzheimer disease (AD) versus other primary causes of dementia (such as frontotemporal dementia (FTD)). Patients with clinical diagnosis of MCI (mild cognitive impairment), probable and possible AD, as well as FTD and nondemented controls were included in the study. CSF levels of t-tau, p-tau-181, p-tau-199, p-tau-231 were measured using commercially available ELISA kits (Invitrogen-Biosource, Camarillo, CA, USA). Mean CSF t-tau and CSF p-tau-181 levels were significantly elevated in AD patients compared to FTD patients and control subjects. Additionally, in differentiation between AD and FTD, CSF p-tau 181 showed best sensitivity and specificity. Our preliminary results in a rather small group of patients with AD and FTD confirmed earlier findings that p-tau-181 may be an useful, promising biological marker for distinguishing primary causes of dementia (e.g. AD from FTD).

Alzheimer's disease; tau protein; cerebrospinal fluid; early-diagnosis; biological markers

European Journal of Neurology (1351-5101) 13 (2006) (S2) 196-197

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

2006.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

European journal of neurology

1351-5101

Podaci o skupu

10th Congress of European Federation of Neurological Societies

poster

02.09.2006-05.09.2006

Glasgow, Ujedinjeno Kraljevstvo

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

Indeksiranost