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Pregled bibliografske jedinice broj: 295821

Časopis

Autori: Starčević, Kristina; Kralj, Marijeta; Ester, Katja; Sabol, Ivan; Grce, Magdalena; Pavelić, Krešimir; Karminski-Zamola, Grace
Naslov: Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles
Izvornik: Bioorganic & medicinal chemistry (0968-0896) 15 (2007), 13; 4419-4426
Vrsta rada: članak
Ključne riječi: benzimidazoles; amidines; N-methylpyrrole; pyridine; imidazole; antiviral activity; antitumor activity
Sažetak:
We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities. The most pronounced antiproliferative activity was shown with compounds 6 and 9, having imidazolinylamidino-substituent. Interestingly, all compounds show remarkable selectivity towards breast cancer cell line MCF-7. The most distinct and selective antiviral activity towards Coxackieviruses and Echoviruses was observed with compounds having pyridine ring at C-2. Especially interesting was fairly strong activity of the compounds 4 and 8 toward adenoviruses, which could be considered as leads against adenoviral replication.
Projekt / tema: 125-0982464-1356, 098-0982464-2514, 098-0982464-2510
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://fulir.irb.hr/2258/1/BMC-S-07-00202%20postprint.pdf
http://dx.doi.org/10.1016/j.bmc.2007.04.032
http://http://www.sciencedirect.com/science/article/pii/S0968089607003501
Broj citata:
Altmetric:
DOI: 10.1016/j.bmc.2007.04.032
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.bmc.2007.04.032
Google Scholar: Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles
Upisao u CROSBI: Grace Karminski-Zamola (gzamola@pierre.fkit.hr), 18. Tra. 2007. u 08:57 sati



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