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Pregled bibliografske jedinice broj: 296693

Zbornik radova

Autori: Janković, Iva; Mirošević, Nikica; Jadrijević-Mladar Takač, Milena; Tomić, Siniša; Macolić-Šarinić, Viola
Naslov: The Siginificance and Severity of Drug-Drug Interactions among all Reported Adverse Drug Events (ADEs) in Croatia
( The Siginificance and Severity of Drug-Drug Interactions among all Reported Adverse Drug Events (ADEs) in Croatia )
Izvornik: 3rd Pharmaceutical Sciences World Congress - Optimising Drug Therapy: An Imperative for World Health, Pre-Satellite Symposium for and by Ph.D. Students and Young Post-Docs 'Young Pharmaceutical Scientists Meet in Amsterdam', Programme and Book of AbstractsThe Hague : International Pharmaceutical Federation, Board of Pharmaceutical Sciences , 2007. 115-116.
Skup: 3rd Pharmaceutical Sciences World Congress - Optimising Drug Therapy: An Imperative for World Health, Pre-Satellite Symposium for and by Ph.D. Students and Young Post-Docs: Young Pharmaceutical Scientists Meet in Amsterdam'
Mjesto i datum: Amsterdam, The Netherlands, 20-21.04.2007.
Ključne riječi: Drug-drug interactions; (DDI); adverse drug event (ADE); pharmaceutical care (PC); pharmacists' intervention
( Drug-drug interactions; (DDI); adverse drug event (ADE); pharmaceutical care (PC); pharmacists' intervention )
Sažetak:
The prevalence of drug-drug interactions (DDIs) among all reported adverse drug events (ADE) to national Agency for medicinal products and medical devices (AMPMD) was investigated. Exploration of significance and severity of drug-drug interactions is in purpose of development of pharmacists’ interventions in preventing further occurrence of drug related problems. This study is set up as both, retrospective and prospective analysis. A retrospective study was conducted on a sample of 498 reports of ADEs reported to national Agency for Medicinal Products and Medical Devices in a period from March to December 2005. A prospective observational study will be carried out from January 2007 until December 2010 where all ADEs due to DDIs reported to Agency will be analysed in the same manner. Identification and confirmation of ADEs due to DDIs was carried out by micromedix program. Results of the analysis showed that among all ADE reports, 32.5% (162) refer to vaccines, while 67.5% (336) refer to all other drugs. Findings showed that 25% of all ADEs are serious. Out of all ADEs 7% were due to DDIs out of which 50% are classified as serious. These findings indicate higher prevalence of drug-drug interactions in Croatia in comparison with world’ s average data (5%). The majority of drugs which caused DDIs belong to N and C ATC group of drugs. The most DDI reports are referred to cyclosporine in concomitant therapy with either fluvastatine or methylprednisolone which resulted in hospitalization and withdrawal of therapy. The association and influence of principal demographic variables (age, gender, number of medicines etc.) on the frequency/prevalence of drug interactions was also explored. Following the results of the retrospective and prospective analysis, research methods for specific pharmacists’ interventions will be developed and its influence measured with the aim of reducing drug related problems.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 098-0982929-2940
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Javno zdravstvo i zdravstvena zaštita,Farmacija
URL Internet adrese: http://www.fip.org/PSWC/
http://pharmacie.univ-lille2.fr/presatelitePSWC/
Upisao u CROSBI: Milena Jadrijević-Mladar Takač (mladar@pharma.hr), 27. Tra. 2007. u 14:53 sati
Napomene:
Rad nagrađen s Young Investigator Poster Award, 1. nagrada u skupini: Clinical Pharmacy/ Pharmacoepidemiology na Pharmaceutical Science World Congress (PSWC) Pre-Satelite Symposium for and by Ph.D. students and Young Post-Docs, na kojem su sudjelovale i rad izlagale (Poster and oral presentation) Iva Janković, znanstvena novakinja i Nikica Mirošević, mlade znanstvenice uključene u istraživanje u ovom radu.



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