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Pregled bibliografske jedinice broj: 301682

Časopis

Autori: Šeparović, Duška; Hanada, Kentaro; Maitah, M. Y.; Nagy, Biserka; Hang, I.; Tainsky, M. A.; Kraniak J. M.; Bielawski, J.
Naslov: Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage
( Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage. )
Izvornik: Biochemical and Biophysical Research Communications (0006-291X) 358 (2007), 1; 196-202
Vrsta rada: članak
Ključne riječi: PDT; SMS1 overexpression; transfection; apoptosis; ceramide; Jurkat cells
( PDT; SMS1 overexpression; transfection; apoptosis; ceramide; Jurkat cells )
Sažetak:
The role of sphingomyelin synthase 1 (SMS1), the Golgi membrane isoform of the enzyme, in ceramide metabolism and apoptosis after photodamage with the photosensitizer Pc 4 (PDT) is unclear. In the present study, using electrospray ionization/double mass spectrometry, we show that in Jurkat cells overexpressing SMS1, increases in ceramides were lower than in empty-vector transfectants post-PDT. Similarly, the responses of dihydroceramides and dihydrosphingosine, precursors of ceramide in the de novo synthetic pathway, were attenuated in SMS1-overexpressor after photodamage, suggesting the involvement of the de novo pathway. Overexpression of SMS1 was associated with differential regulation of sphingomyelin levels, as well as with the reduced inhibition of the enzyme post-treatment. Concomitant with the suppressed ceramide response, PDT-induced DEVDase activation was substantially reduced in SMS1-overexpressors. The data show that overexpression of SMS1 is associated with suppressed ceramide response and apoptotic resistance after photodamage.
Projekt / tema: 119-0000000-1256
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage
Upisao u CROSBI: Biserka Nagy (biserka.nagy@zg.tel.hr), 9. Srp. 2007. u 22:57 sati



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