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Pregled bibliografske jedinice broj: 303136

Časopis

Autori: Kosor-Krnić, Ela; Gagro, Alenka; Kozarić- Kovačić, Dragica; Vilibić, Maja; Grubišić-Ilić, Mirjana; Folnegović Šmalc, Vera; Draženović, Vladimir; Čečuk-Jeličić, Esma; Gjenero -Margan, Ira; Kuzman, Ilija; Jeren, Tatjana; Sabioncello, Ante; Kerhin-Brkljačić, Vesna; Kaić, Bernard; Markotić, Alemka; Gotovac, Katja; Rabatić, Sabina; Mlinarić-Galinović, Gordana; Dekaris, Dragan
Naslov: Outcome of influenza vaccination in combat-retated post-traumatic stress disorder (PTSD) patients
( Outcome of influenza vaccination in combat-related post-traumatic stress disorder (PTSD) patients )
Izvornik: Clinical and Experimental Immunology (0009-9104) 149 (2007), 2; 303-310
Vrsta rada: članak
Ključne riječi: influenza vaccination; PTSD; war veterans
( influenza vaccination; PTSD; war veterans )
Sažetak:
Post-traumatic stress disorder (PTSD) is an anxiety disorder that can occur after exposure to extreme traumatic experience such as war trauma, and is accompanied by fear, helplessness or horror. Exposure to trauma can result in immune dysregulation and influence susceptibility to infectious disease as well as vaccine efficacy. The aim of the study was to determine the relation of psychological stress and the immune response to influenza vaccination in combat-related PTSD patients (n = 28). Detection of anti-viral antibody titre was performed by inhibition of haemagglutination assay. Ex vivo tetramer staining of CD8(+) T lymphocytes was used to monitor T cells specific for human leucocyte antigen (HLA)-A*0201-restricted influenza A haemagglutinin antigens before and after vaccination. Twenty patients showed a fourfold antibody titre increase to one or both influenza A viral strains, and 18 of them showed the same response for both influenza B viral strains. Ten of 15 healthy controls showed a fourfold rise in antibody titre to both influenza A viral strains and eight of them showed the same response for both influenza B viral strains. HLA-A*0201(+) PTSD patients (n = 10) showed a significant increase of influenza-specific CD8 T cells after vaccination. Although those PTSD patients had a lower number of influenza-specific CD8(+) T cells before vaccination compared to HLA-A*0201(+) healthy controls (n = 6), there was no difference in influenza A antibody titre between PTSD patients and control subjects before vaccination. The generated humoral and cellular immune response in PTSD patients argues against the hypothesis that combat-related PTSD in war veterans might affect protection following influenza vaccination.
Projekt / tema: 072-1080229-0337, 198-0982522-0075, 021-0212432-2434, 198-1081870-0074, 143-1430115-0103
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1365-2249.2007.03410.x
URL cjelovitog teksta:
Google Scholar: Outcome of influenza vaccination in combat-retated post-traumatic stress disorder (PTSD) patients
Upisao u CROSBI: Tina Peraica (tina.peraica@kbd.hr), 26. Srp. 2007. u 10:44 sati



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