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Pregled bibliografske jedinice broj: 306881

Zbornik radova

Autori: Brizić, Ivica; Lukšić, Boris; Modun, Darko; Vuković, Jonatan; Musić, Ivana; Boban, Mladen
Naslov: Cardioprotective effects of 2, 3-butanendione monoxime against the vipera ammodytes ammodytes venom in the isolated rat heart
( Cardioprotective effects of 2, 3-butanendione monoxime against the vipera ammodytes ammodytes venom in the isolated rat heart )
Izvornik: Periodicum Biologorum, Vol 109, Suppl 2 / Vitale, Branko (ur.). - Zagreb : Hrvatsko prirodoslovno društvo, Frankopanska 1, Zagreb , 2007. 110.
ISSN: 0031-5362
Skup: 5th Croatian congress of pharmacology and 2nd Congress of Croatian Physiological society
Mjesto i datum: Osijek, Hrvatska, 19. - 22. 09. 2007
Ključne riječi: Cardioprotection; Venom; Snake; BDM; Isolated Heart
( Cardioprotection; Venom; Snake; BDM; Isolated Heart )
Sažetak:
The nose-horned viper, Vipera ammodytes ammodytes, the most venomous snake in Europe is widespread in its southeastern part, including Croatia. The venoms of Viperinae family cause local tissue damage and systemic symptoms, including cardio circulatory disturbances. The aim of this study was to examine the cardioprotective effects of 2, 3-butanendione monoxime (BDM), a potent negative inotropic and vasodilatatory agent that causes excitation-contraction uncoupling in muscles. The effects of BDM were compared with effects of cyclooxygenase inhibitor (indomethacin), lipoxygenase inhibitor (nordihydroguaiaretic acid (NDGA)), inhibitor cytochrome P450 enzymes (clotrimazole), L-type Ca2+ channels blocker (verapamil) and phospholipase A2 inhibitor (quinacrine), agents that have been shown to have cardioprotective effects against different snake venoms. Under in vitro conditions BDM proved to be very effective protector against cardio toxic effects of the nose-horned viper venom. Further studies under in vivo conditions are warranted.
Rad je indeksiran u
bazama podataka:
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 216-2160547-0537
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Darko Modun (dmodun@bsb.mefst.hr), 2. Lis. 2007. u 12:06 sati



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