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Pregled bibliografske jedinice broj: 309518

Časopis

Autori: Pizent, Alica; Macan, Jelena; Jurasović, Jasna; Varnai, Veda Marija; Milković-Kraus, Sanja; Kanceljak-Macan, Božica
Naslov: Association of toxic and essential metals with atopy markers and ventilatory lung function in women and men
( Association of toxic and essential metals with atopy markers and ventilatory lung function in women and men )
Izvornik: Science of Total Environment (0048-9697) 390 (2008), 2-3; 369-376
Vrsta rada: članak
Ključne riječi: toxic and essential metals; antioxidant enzymes; atopy; ventilatory function; airway reactivity
( toxic and essential metals; antioxidant enzymes; atopy; ventilatory function; airway reactivity )
Sažetak:
The association of age, smoking, alcohol, superoxide dismutase (SOD), glutathione peroxidase (GPx), blood lead (BPb) and cadmium (BCd) levels, and serum levels of copper (SCu), zinc (SZn) and selenium (SSe) with atopic status and ventilatory function was examined in the groups of 166 women and 50 men with no occupational exposure to metals or other xenobiotics. Markers of atopy included serum total IgE, skin prick test (SPT) to common inhalatory allergens, non-specific nasal reactivity (NNR) and non-specific bronchial reactivity (NBR). Parameters of ventilatory function included forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1 ). Significantly (P<0.05) higher BPb, SZn, IgE and prevalence of positive SPT, and lower SCu and NNR was found in men than in women. Fifteen women taking female sex hormones (HT) had significantly higher SCu than women without HT (1437 vs 1111 μ g/L, respectively ; P<0.0001). Regression models showed significant inverse associations between IgE and SCu (P=0.021) and NNR and SCu (P=0.044) in women. When excluding women with HT, the association of SCu and total IgE became of borderline significance (P=0.051), association between SCu and NNR disappeared, and significant positive association between total IgE and blood Pb emerged (P=0.046). In men, significant inverse association was found between positive SPT and SSe, and between NBR and SSe. A decrease in FVC% and FEV1% was associated with an increase in smoking intensity (P<0.001) and a decrease in SZn (P=0.043 and P=0.053, respectively). These results were observed at the levels of the metals comparable to those in general populations worldwide. The observed differences between men and women may partly be explained by different levels of relevant toxic and essential metals, and their combination. The role of female HT in associations of atopy markers and SCu should be further investigated.
Projekt / tema: 022-0222411-2408, 022-0222411-2410
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Javno zdravstvo i zdravstvena zaštita
URL cjelovitog teksta:
Google Scholar: Association of toxic and essential metals with atopy markers and ventilatory lung function in women and men
Upisao u CROSBI: Jelena Macan (jmacan@imi.hr), 26. Lis. 2007. u 18:12 sati



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