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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 317651

Časopis

Autori: Jugović, Domagoj; Medić, Marijana; Kušan-Jukić, Marija; Tumbri, Jasna; Kurjak, Asim; Arbeille, Philippe; Salihagić-Kadić, Aida
Naslov: New Doppler index for prediction of perinatal brain damage in growth-restricted and hypoxic fetuses
( New Doppler index for prediction of perinatal brain damage in growth-restricted and hypoxic fetuses )
Izvornik: Ultrasound in Obstetrics & Gynecology (0960-7692) 30 (2007), 3; 303-311
Vrsta rada: članak
Ključne riječi: brain damage; fetal hypoxia; Doppler; IUGR; neonatal ultrasound
( brain damage; fetal hypoxia; Doppler; IUGR; neonatal ultrasound )
Sažetak:
To evaluate the new vascular score, hypoxia index (HI), in the prediction of sonographically detected structural brain lesions in neonates within the first week after delivery of growth-restricted fetuses. METHODS: This prospective study included 29 growth-restricted fetuses delivered between 31 and 40 gestational weeks. Doppler umbilical artery (UA) and middle cerebral artery (MCA) resistance indices (RI) were recorded at 48-h intervals for at least 2 weeks before delivery. The cerebroumbilical ratio (C/U ratio = MCA-RI/UA-RI) and the HI (the sum of the daily reductions in C/U ratio, i.e. percentage below the cut-off value of 1, over the period of observation) were calculated. After delivery, neonatal outcome was evaluated according to obstetric parameters and ultrasound examinations of the brain. Doppler indices, C/U ratio and HI, as well as neonatal clinical and biochemical parameters, were tested as potential predictors of brain lesions using the C4.5 data-mining algorithm. RESULTS: Neonatal brain lesions were detected in 13 growth-restricted fetuses. Of all the parameters tested by the C4.5 data-mining algorithm, only HI was identified as a predictor of neonatal brain lesions. HI also showed better correlation with neonatal biochemical parameters, such as umbilical venous partial pressure of oxygen and umbilical venous pH, compared with the C/U ratio. CONCLUSIONS: HI, which takes into account cumulative oxygen deficit, could significantly improve the prediction of a poor neurological outcome in pregnancies complicated by growth restriction and hypoxia.
Projekt / tema: 108-1081870-1940
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: New Doppler index for prediction of perinatal brain damage in growth-restricted and hypoxic fetuses
Upisao u CROSBI: Maja Predojević (mpredoje@mef.hr), 11. Sij. 2008. u 18:01 sati



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