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Pregled bibliografske jedinice broj: 319342

Časopis

Autori: Tomasović, Maja; Rešić, Biserka; Ivelja, Nada; Kuzmanić-Šamija, Radenka; Rešić, Jasminka; Gabrić Pandurić, Dragana; Božić, Joško; Markotić, Anita
Naslov: Glycosphingolipid exprassion in cerebrospinal fluid of infants with neurological abnormalities: report of three cases
Izvornik: Collegium Antropologicum (0350-6134) 32 (2008), S1; 189-193
Vrsta rada: članak
Ključne riječi: idiopathic West syndrome; Reye like syndrome; congenital hydrocephalus; cerebrospinal fluid; glycosphingolipids
Sažetak:
The aim of this study was to analyse glycosphingolipids expression in cerebrospinal fluid (CSF) from one idiopathic West syndrome (IWS) infant, one with Reye like syndrome, and one with congenital hydrocephalus, in comparison to control group (n=7) using highly sensitive thin-layer chromatography-immunostaining methods. Gangliotetraose-series gangliosides (acidic glycosphingolipids) were not detected in CSF of infant with idiopathic West syndrome and infant with congenital hydrocephalus. CSF of infant with IWS showed traces of neolacto-tetraose ganglioside fractions, which were absent in all other CSF examined. In addition, lactosylceramide fraction, and one ceramide fraction were highly expressed only in IWS CSF. these results confirmed previously described lack of gangliotetraose-series gangliosides in IWS patient and for the first time is described increased expression of neolacto-series glycosphingolipids in IWS patient. Since follow up until the age of five years showed almost normal IWS patient psychomotor development, the discribed shift of glycosphingolipid expression may implicate on transient inhibition of specific glycosyl fransferases in the age og seven months.
Projekt / tema: 216-2160133-0066, 065-0000000-0424
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Stručni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
Puni text rada: 319342.tomasovic_20_12_071.pdf (tekst priložen 27. Ožu. 2008. u 09:50 sati)
URL cjelovitog teksta:
Google Scholar: Glycosphingolipid exprassion in cerebrospinal fluid of infants with neurological abnormalities: report of three cases
Upisao u CROSBI: Dragana Gabrić (dgabric@sfzg.hr), 24. Sij. 2008. u 11:34 sati



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