CSF levels of total tau, tau protein phosphorylated at threonine 181 and serine 199 as predictors of Alzheimer's disease in patients with mild cognitive impairment (CROSBI ID 533258)
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Podaci o odgovornosti
Boban, Marina ; Grbić, Kristina ; Hof R. Patrick ; Süßmair, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian ; Šimić, Goran
engleski
CSF levels of total tau, tau protein phosphorylated at threonine 181 and serine 199 as predictors of Alzheimer's disease in patients with mild cognitive impairment
Patients with mild cognitive impairment (MCI), especially those with the amnestic type of MCI, have an elevated risk for development of Alzheimer’ s disease (AD). Since treatment for AD is likely to have the best efficacy in the early or even preclinical phase of the disease, it is necessary to find biomarkers which would help to identify incipient AD in MCI cohorts. Our objective was to investigate the value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau-181) and at serine 199 (p-tau-199) for the prediction of AD among patients with MCI. Patients with a clinical diagnosis of MCI-amnestic type as well as healthy controls were included. CSF levels of t-tau, p-tau-181 and p-tau-199 were measured using commercially available ELISA kits (Innogenetics, Ghent, Belgium ; Biosource International, Camarillo, CA, USA). After two years of follow-up MCI patients were divided in two groups: “ stable MCI” or “ MCI converters” (those who progressed to AD). Our preliminary results showed that CSF levels of t-tau and p-tau-181 proteins were significantly elevated in MCI converters compared to stable MCI patients and healthy controls. We therefore concluded that CSF levels of t-tau and p-tau-181 could be valuable markers of early AD in patients with MCI and, consequently, for early selection of patients for treatment.
Alzheimer's disease; cerebrospinal fluid; early diagnosis; ELISA; mild cognitive impairment; phoshorylated epitopes; tau proteins
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Podaci o prilogu
95-95-x.
2007.
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objavljeno
Podaci o matičnoj publikaciji
European journal of neurology
Brisel: EFNS
1351-5101
Podaci o skupu
11th Congress of the European Federation of neurological Societies,
poster
25.08.2007-28.08.2007
Bruxelles, Belgija
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija