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CSF levels of total tau, tau protein phosphorylated at threonine 181 and serine 199 as predictors of Alzheimer's disease in patients with mild cognitive impairment (CROSBI ID 533258)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Boban, Marina ; Grbić, Kristina ; Hof R. Patrick ; Süßmair, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian ; Šimić, Goran CSF levels of total tau, tau protein phosphorylated at threonine 181 and serine 199 as predictors of Alzheimer's disease in patients with mild cognitive impairment // European journal of neurology. 2007. str. 95-95-x

Podaci o odgovornosti

Boban, Marina ; Grbić, Kristina ; Hof R. Patrick ; Süßmair, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian ; Šimić, Goran

engleski

CSF levels of total tau, tau protein phosphorylated at threonine 181 and serine 199 as predictors of Alzheimer's disease in patients with mild cognitive impairment

Patients with mild cognitive impairment (MCI), especially those with the amnestic type of MCI, have an elevated risk for development of Alzheimer’ s disease (AD). Since treatment for AD is likely to have the best efficacy in the early or even preclinical phase of the disease, it is necessary to find biomarkers which would help to identify incipient AD in MCI cohorts. Our objective was to investigate the value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau-181) and at serine 199 (p-tau-199) for the prediction of AD among patients with MCI. Patients with a clinical diagnosis of MCI-amnestic type as well as healthy controls were included. CSF levels of t-tau, p-tau-181 and p-tau-199 were measured using commercially available ELISA kits (Innogenetics, Ghent, Belgium ; Biosource International, Camarillo, CA, USA). After two years of follow-up MCI patients were divided in two groups: “ stable MCI” or “ MCI converters” (those who progressed to AD). Our preliminary results showed that CSF levels of t-tau and p-tau-181 proteins were significantly elevated in MCI converters compared to stable MCI patients and healthy controls. We therefore concluded that CSF levels of t-tau and p-tau-181 could be valuable markers of early AD in patients with MCI and, consequently, for early selection of patients for treatment.

Alzheimer's disease; cerebrospinal fluid; early diagnosis; ELISA; mild cognitive impairment; phoshorylated epitopes; tau proteins

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Podaci o prilogu

95-95-x.

2007.

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objavljeno

Podaci o matičnoj publikaciji

European journal of neurology

Brisel: EFNS

1351-5101

Podaci o skupu

11th Congress of the European Federation of neurological Societies,

poster

25.08.2007-28.08.2007

Bruxelles, Belgija

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

Indeksiranost