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Pregled bibliografske jedinice broj: 325044

Časopis

Autori: Lukšić, Boris; Brizić, Ivica; Lang Balija, Maja; Modun, Darko; Ćulić, Viktor; Halassy, Beata; Salamunić, Ilza; Boban, Mladen
Naslov: Dose dependent effects of standardized nose-horned viper (Vipera ammodytes ammodytes) venom on parameters of cardiac function in isolated rat heart
( Dose dependent effects of standardized nose-horned viper (Vipera ammodytes ammodytes) venom on parameters of cardiac function in isolated rat heart )
Izvornik: Comparative Biochemistry and Physiology C, Toxicology & Pharmacology (1532-0456) 147 (2008), 4; 434-440
Vrsta rada: članak
Ključne riječi: Cardiotoxicity; Isolated heart; Snake venom; Vipera ammodytes ammodytes
( Cardiotoxicity; Isolated heart; Snake venom; Vipera ammodytes ammodytes )
Sažetak:
Direct, dose dependent effects of the nose-horned vipers' (Vipera ammodytes ammodytes) venom on various parameters of cardiac action in isolated rat hearts were examined. Biochemical (protein content, SDS polyacrylamide gel electrophoresis) and biological (minimum haemorrhagic and necrotizing dose and lethal dose (LD50)) characterization of the venom was performed before testing. The hearts were infused with venom doses of 30, 90 and 150 μ g/mL for 10 min followed by 30 min of wash out period. Left ventricular pressure, coronary flow, heart rate, atrioventricular conduction, myocardial oxygen consumption, incidence and duration of arrhythmias were measured and relative cardiac efficiency was calculated. Cardiac CPK, LDH, AST and troponin I were measured as biochemical markers of myocardial damage. The venom caused dose dependent electrophysiological instability and depression of contractility and coronary flow. Effects on the heart rate were biphasic ; transient increase followed by significant slowing of the frequency. Relative cardiac efficiency decreased as oxygen consumption remained high relative to the heart rate-contractility product, indicating purposeless expenditure of oxygen and energy. Effects by the dose of 30 μ g/mL were highly reversible while the dose of 90 μ g/mL caused damages that were mostly irreversible. The dose of 150 μ g/mL induced irreversible asystolic cardiac arrest.
Projekt / tema: 021-0212432-2033, 216-2160547-0537
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Dose dependent effects of standardized nose-horned viper (Vipera ammodytes ammodytes) venom on parameters of cardiac function in isolated rat heart
Upisao u CROSBI: Beata Halassy Špoljar (bhalassy@imz.hr), 12. Ožu. 2008. u 10:57 sati



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