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Pregled bibliografske jedinice broj: 325795

Časopis

Autori: Wittine, Karlo; Benci, Krešimir; Rajić, Zrinka; Zorc, Branka; Kralj, Marijeta; Marjanović, Marko; Pavelić, Krešimir; De Clercq, Eric; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Mintas, Mladen
Naslov: The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
Izvornik: European journal of medicinal chemistry (0223-5234) 44 (2009), 1; 143-151
Vrsta rada: članak
Ključne riječi: Nonsteroidal Anti-Inflammatory Drugs (NSAID); 3-Hydroxypropylamides; Phosphoramidates; Cytostatic Activity
Sažetak:
The target phosphoramidates 5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a-e and 5a-e were evaluated for their cytostatic and antiviral activity against malignant tumour cell lines and normal human fibroblasts (WI38). All phosphoramidate derivatives 5a-e possess significantly greater inhibitory activities than the corresponding 3-hydroxypropyl derivatives 3a-e, whereby compound 5a showed the most potent inhibitory activities against cervical, pancreatic and colon carcinoma cell lines (IC50 = 5 7  M).
Projekt / tema: 098-0982464-2514, 125-0982464-2922, 098-0982464-2393, 006-0000000-3216
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Farmacija
URL Internet adrese: http://dx.doi.org/10.1016/j.ejmech.2008.03.037
http://www.sciencedirect.com/science/article/pii/S0223523408001621
http://ac.els-cdn.com/S0223523408001621/1-s2.0-S0223523408001621-main.pdf?_tid=f19ec47e67f6f098562718951fd26a33&acdnat=1338462398_598397ff9a39031d9af97ba9e5ab6b85
Broj citata:
Altmetric:
DOI: 10.1016/j.ejmech.2008.03.037
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.ejmech.2008.03.037
Google Scholar: The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
Upisao u CROSBI: Mladen Mintas (mmintas@fkit.hr), 19. Ožu. 2008. u 15:57 sati



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