The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations (CROSBI ID 137345)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Wittine, Karlo ; Benci, Krešimir ; Rajić, Zrinka ; Zorc, Branka ; Kralj, Marijeta ; Marjanović, Marko ; Pavelić, Krešimir ; De Clercq, Eric ; Andrei, Graciela ; Snoeck, Robert ; Balzarini, Jan ; Mintas, Mladen
engleski
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
The target phosphoramidates 5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a-e and 5a-e were evaluated for their cytostatic and antiviral activity against malignant tumour cell lines and normal human fibroblasts (WI38). All phosphoramidate derivatives 5a-e possess significantly greater inhibitory activities than the corresponding 3-hydroxypropyl derivatives 3a-e, whereby compound 5a showed the most potent inhibitory activities against cervical, pancreatic and colon carcinoma cell lines (IC50 = 5 7 M).
Nonsteroidal Anti-Inflammatory Drugs (NSAID) ; 3-Hydroxypropylamides ; Phosphoramidates ; Cytostatic Activity
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Podaci o izdanju
44 (1)
2009.
143-151
objavljeno
0223-5234
1768-3254
10.1016/j.ejmech.2008.03.037
Povezanost rada
Kemija, Temeljne medicinske znanosti, Farmacija