crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 331113

Zbornik radova

Autori: Milić, Mirta; Pizent, Alica; Kljaković-Gašpić, Zorana; Rozgaj, Ružica; Kašuba, Vilena
Naslov: Micronuclei and trace elements in lead workers
( Micronuclei and trace elements in lead workers )
Izvornik: Abstracts of the Abstracts of the 44th Congress of the European Societies of Toxicology (Eurotox 2007) ; u: Toxicology Letters 172 (2008) (S1) S1-S240 ; P5: Occupational and Environmental Health ; O21 / Dekant, Wolfgang (ur.). - Amsterdam : Elsevier , 2007. S119-S120.
ISSN: 0378-4274
Skup: Congress of the European Societies of Toxicology (44 ; 2007)
Mjesto i datum: Amsterdam, Nizozemska, 07.-10.10.2007.
Ključne riječi: trace elements; micronucleus; lead workers
( trace elements; micronucleus; lead workers )
Sažetak:
Micronuclei (MN) in blood lymphocytes, blood lead (BPb), activity of erythrocyte delta-aminolevulinic acid dehydratase (ALAD), erythrocyte protoporphyrin (EP), serum copper (SCu) and serum zinc (SZn) were measured in 46 subjects 21-56 years of age, including 34 lead workers and 12 control subjects with no-occupational exposure to lead. The results of BPb, ALAD and EP showed a highly significant (P=0.0000) difference in lead exposure between the groups. Significantly higher MN (P< 0.001) and significantly lower SCu (P< 0.02) were found in lead workers, whereas no significant difference between the groups was found for SZn. The results in all 46 subjects showed an increase in MN with an increase in log BPb (r=0.350, P< 0.02), a decrease in ALAD (r= - 0.293, P< 0.03), and a decrease in SCu (r= - 0.324, P< 0.03). The results of partial correlations confirmed significant negative correlation between MN and SCu after controlling for lead exposure (BPb, ALAD, EP). In contrast to expected pro-oxidative activity of copper through formation of micronuclei, our results indicate possible beneficial role of copper in maintenance of genomic stability. In that sense, participation of copper in antioxidative defense (as a co-factor of antioxidative enzyme copper, zinc-superoxide dismutase) could have an important role. However, our small sample size may have been a potential limitation in making final conclusions. Therefore, further epidemiological research in evaluating the role of trace elements in genomic (in)stability is recommended.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 022-0222148-2137, 022-0222411-2408
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Biologija
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TCR-4PKH640-9V-1&_cdi=5177&_user=3875467&_orig=search&_coverDate=10%2F07%2F2007&_sk=998279999.8998&view=c&wchp=dGLbVzb-zSkWz&md5=d7c970087df5f41e5b5b6fa6b8dd903c&ie=/sdarticle.pdf
Upisao u CROSBI: vkasuba@imi.hr (vkasuba@imi.hr), 25. Tra. 2008. u 10:36 sati
Napomene:
doi:10.1016/j.toxlet.2007.05.318



  Verzija za printanje   za tiskati


upomoc
foot_4