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Autori: Pizent, Alica; Macan, Jelena; Jurasović, Jasna; Varnai, Veda Marija; Kanceljak-Macan, Božica
Naslov: Influence of toxic and essential metals on markers of atopy and ventilatory function in men and women
( Influence of toxic and essential metals on markers of atopy and ventilatory function in men and women )
Izvornik: Abstracts for a conference on trace elements in diet, nutrition, and health: essentiality and toxicity. Cell Biol Toxicol 24 (Suppl 1) / Nordberg, Monica (ur.). - Springer , 2008. S54.
ISSN: 1573-6822
Skup: ISTERH-NTES-HTES A Joint Conference on Trace Elements in Diet, Nutrition, and Health: Essentiality and Toxicity
Mjesto i datum: Hersonissos, Kreta-Grčka, 21.-26. 10. 2007.
Ključne riječi: Toxic and essential metals; anti-oxidant enzymes; atopy; ventilatory function; airway reactivity
( Toxic and essential metals; anti-oxidant enzymes; atopy; ventilatory function; airway reactivity )
Sažetak:
The combined influence of age, smoking, alcohol, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx) in whole blood, blood lead (BPb), and cadmium (BCd) levels, and serum levels of copper (SCu), zinc (SZn), and selenium (SSe) on atopic status and ventilatory function was examined in the groups of men and women with no occupational exposure to metals. Markers of atopy included serum total IgE, skin prick test (SPT) to common inhalatory allergens, nonspecific nasal reactivity (NR) and nonspecific bronchial reactivity (BR). Parameters of ventilatory function included forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), each expressed as percentage. A significantly (p<0.05) higher BPb, SZn, IgE, and incidence of positive SPT and lower SCu and NR was found in men than in women. In men, IgE inversely correlated with SSe (p<0.03), and FVC% and FEV1% inversely correlated with smoking intensity (p<0.0001 and p<0.005, respectively) and BCd (p<0.007 and p<0.005, respectively). In women, IgE positively correlated with BPb (p<0.02), and NR positively correlated with GPx (p<0.02). After adjusting for potentially confounding variables by multiple regression in the group of men, an increase in BR was associated with an increase in age (p<0.01) and a decrease in SSe (p<0.01) and log BPb (p<0.02) ; a decrease in FVC% was associated with an increase in smoking intensity (p<0.0002) and a decrease in SZn (p<0.05) ; a decrease in FEV1% was associated with an increase in smoking intensity (p<0.002) and SOD (p<0.05), and a decrease in SZn (p=0.05). In women, an increase in log IgE was associated with a decrease in SCu (p<0.05) ; an increase in NR was associated with an increase in GPx (p<0.02) and a decrease in SCu (p<0.05). The observed difference in response between the groups of men and women may partly be explained by different levels of relevant toxic and essential metals and particularly their combination.
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bazama podataka:
MEDLINE
Scopus
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 022-0222411-2408, 022-0222411-2410
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Javno zdravstvo i zdravstvena zaštita
Upisao u CROSBI: apizent@imi.hr (apizent@imi.hr), 25. Tra. 2008. u 16:47 sati
Napomene:
DOI : 10.1007/s10565-007-9052-8 ; SpringerLink Date: Wednesday, January 16, 2008



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