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Influence of toxic and essential metals on markers of atopy and ventilatory function in men and women (CROSBI ID 534739)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Pizent, Alica ; Macan, Jelena ; Jurasović, Jasna ; Varnai, Veda Marija ; Kanceljak-Macan, Božica Influence of toxic and essential metals on markers of atopy and ventilatory function in men and women // Cell biology and toxicology / Nordberg, Monica (ur.). 2008. str. S54-x

Podaci o odgovornosti

Pizent, Alica ; Macan, Jelena ; Jurasović, Jasna ; Varnai, Veda Marija ; Kanceljak-Macan, Božica

engleski

Influence of toxic and essential metals on markers of atopy and ventilatory function in men and women

The combined influence of age, smoking, alcohol, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx) in whole blood, blood lead (BPb), and cadmium (BCd) levels, and serum levels of copper (SCu), zinc (SZn), and selenium (SSe) on atopic status and ventilatory function was examined in the groups of men and women with no occupational exposure to metals. Markers of atopy included serum total IgE, skin prick test (SPT) to common inhalatory allergens, nonspecific nasal reactivity (NR) and nonspecific bronchial reactivity (BR). Parameters of ventilatory function included forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), each expressed as percentage. A significantly (p<0.05) higher BPb, SZn, IgE, and incidence of positive SPT and lower SCu and NR was found in men than in women. In men, IgE inversely correlated with SSe (p<0.03), and FVC% and FEV1% inversely correlated with smoking intensity (p<0.0001 and p<0.005, respectively) and BCd (p<0.007 and p<0.005, respectively). In women, IgE positively correlated with BPb (p<0.02), and NR positively correlated with GPx (p<0.02). After adjusting for potentially confounding variables by multiple regression in the group of men, an increase in BR was associated with an increase in age (p<0.01) and a decrease in SSe (p<0.01) and log BPb (p<0.02) ; a decrease in FVC% was associated with an increase in smoking intensity (p<0.0002) and a decrease in SZn (p<0.05) ; a decrease in FEV1% was associated with an increase in smoking intensity (p<0.002) and SOD (p<0.05), and a decrease in SZn (p=0.05). In women, an increase in log IgE was associated with a decrease in SCu (p<0.05) ; an increase in NR was associated with an increase in GPx (p<0.02) and a decrease in SCu (p<0.05). The observed difference in response between the groups of men and women may partly be explained by different levels of relevant toxic and essential metals and particularly their combination.

Toxic and essential metals; anti-oxidant enzymes; atopy; ventilatory function; airway reactivity

DOI : 10.1007/s10565-007-9052-8 ; SpringerLink Date: Wednesday, January 16, 2008

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Podaci o prilogu

S54-x.

2008.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Cell biology and toxicology

Nordberg, Monica

Springer

1573-6822

Podaci o skupu

Nepoznat skup

poster

29.02.1904-29.02.2096

Povezanost rada

Javno zdravstvo i zdravstvena zaštita

Indeksiranost