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Pregled bibliografske jedinice broj: 333732

Časopis

Autori: Domitrović, Robert; Tota, Marin; Milin, Čedomila
Naslov: Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets
( Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets )
Izvornik: Nutrition Research (0271-5317) 28 (2008), 4; 263-269
Vrsta rada: članak
Ključne riječi: olive oil; corn oil; diet; iron; retinol; alpha-tocopherol; TBARS; mice
( olive oil; corn oil; diet; iron; retinol; alpha-tocopherol; TBARS; mice )
Sažetak:
The influence of dietary fats on cellular alpha-tocopherol and retinol uptake in iron overload is poorly understood. The aim of this study was to investigate the effect of a high-iron diet on the retinol and alpha-tocopherol levels in mice fed olive oil– and corn oil– enriched diets. Mice were fed for 3 weeks a standard mouse chow (the control group) and diets enriched with 5% by weight of corn oil or olive oil. Diets of the mice fed corn oil and olive oil were additionally supplemented with 1% by weight carbonyl iron. Both dietary oils and iron increased the liver iron uptake. High-iron feeding induced oxidative stress in mice liver, measured as a thiobarbituric acid-reactive substance level. Both fats and iron induced changes in the liver fatty acid composition. Liver retinol and alpha-tocopherol stores increased with iron supplementation in the olive oil– enriched diet, with a simultaneous decrease in serum. The results suggest that the influx of alpha-tocopherol and retinol from serum to the liver is induced by high dietary iron. This redistribution appears to be stronger for retinol than for alpha-tocopherol and is also higher in mice fed olive oil than in mice fed corn oil, suggesting that the composition of dietary lipids is important in the treatment of high-iron tissue conditions. In conclusion, the results of this study suggest that the increase of hepatic alpha-tocopherol and retinol levels in the olive oil– based diet is a dietary-dependent responsive mechanism that probably is not primarily related to an increased risk of oxidative damage induced by high-iron intake.
Projekt / tema: 062-0000000-3554, 062-0621341-0061
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TB1-4S7J1X7-8-9&_cdi=5129&_user=3875467&_orig=search&_coverDate=04%2F30%2F2008&_sk=999719995&view=c&wchp=dGLbVtz-zSkWz&md5=388c986d3197094c87fc47f9646a9304&ie=/sdarticle.pdf
Broj citata:
Altmetric:
DOI: 10.1016/j.nutres.2008.01.007
URL cjelovitog teksta:
Google Scholar: Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets
Upisao u CROSBI: robertd@medri.hr (robertd@medri.hr), 29. Tra. 2008. u 17:33 sati



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