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Pregled bibliografske jedinice broj: 340474

Časopis

Autori: Marković, Vinko; Eterović, Davor
Naslov: Thyroid echogenicity predicts outcome of radioiodine therapy in patients with Graves' disease
( Thyroid echogenicity predicts outcome of radioiodine therapy in patients with Graves' disease )
Izvornik: Journal of Clinical Endocrinology & Metabolism (0021-972X) 92 (2007), 9; 3547-4552
Vrsta rada: članak
Ključne riječi: radioactive iodine therapy; follow-up; hyperthyroidism; propylthiouracil; pretreatment; study; risk; age
( radioactive iodine therapy; follow-up; hyperthyroidism; propylthiouracil; pretreatment; study; risk; age )
Sažetak:
Despite accounting for variations in gland size and iodine kinetics, the success of radioiodine therapy in patients with Graves' disease remains moderately common and unpredictable. Objectives: We hypothesized that hypoechogenic glands, with large, densely packed cells, are more radiosensitive than normoechogenic glands, in which much radiation is wasted on more abundant colloid. We evaluated this hypothesis in a cohort of patients with Graves' disease. Design: This was a prospective trial of patients recruited during 4 yr and followed up 1 yr after radioiodine therapy. Setting: This trial was held in a university hospital-outpatient clinic. Patients: A total of 177 consecutive patients with first presentation of Graves' disease ( 28 males), 23-76 yr old, who relapsed after antithyroid therapy were included in the study. Intervention: The patients were assigned to an ablative target-absorbed dose of 200 Gy (n =78) or randomly to 100 or 120 Gy of nonablative dose ( n = 99). Main Outcome Measures: The measures were incidences of hyperthyroidism, euthyroidism, and hypothyroidism at 12-month follow-up. Results: At follow-up there were 25 hyperthyroid, 44 euthyroid, and 108 hypothyroid patients. Compared with 96 patients with a hypoechogenic gland, in 81 patients with a normoechogenic gland, there were more hyperthyroid ( 22 vs. 7%) and euthyroid ( 41 vs. 11%), but less hypothyroid outcomes ( 37 vs. 81% ; P < 0.0001). The other independent predictor of increased radioresistance was the large gland volume. Conclusion: In patients with Graves' disease, normoechogenic and large glands are associated with increased radioresistance.
Projekt / tema: 216-0000000-0216
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Broj citata:
Altmetric:
DOI: 10.1210/jc.2007-0879
URL cjelovitog teksta:
Google Scholar: Thyroid echogenicity predicts outcome of radioiodine therapy in patients with Graves' disease
Upisao u CROSBI: deterovi@mefst.hr (deterovi@mefst.hr), 6. Svi. 2008. u 15:42 sati



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