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Pregled bibliografske jedinice broj: 340489

Časopis

Autori: Borović, Suzana; Čipak, Ana; Meinitzer, Andreas; Kejla, Zvonko; Perović, Darko; Waeg, Georg; Žarković, Neven
Naslov: Differential sensitivity to 4-hydroxynonenal for normal and malignant mesenchymal cells
Izvornik: Redox report (1351-0002) 12 (2007), 1/2; 50-54
Vrsta rada: članak
Ključne riječi: 4-hydroxynonenal; mesenchymal cells; human osteosarcoma; human osteoblasts; apoptosis; hne-his elisa; glutathione; persistent oxidative stress; human osteosarcoma cells; lipid-peroxidation; glutathione; conjugation; cancer; localization; products; adducts; tissues
Sažetak:
Normal and malignant cells of various origin differ in their sensitivity to oxidative stress. Therefore, we used normal and malignant mesenchymal cells-human osteosarcoma cells (HOS and 143B), human fibroblasts (WI38) and two primary cultures of normal human osteoblasts to test sensitivity to reactive aldehyde 4- hydroxynonenal (HNE), known as a second messenger of free radicals and a signaling molecule. Upon HNE-treatment, decrease in cell viability (by Trypan-blue), apoptosis induction (by TiterTACS (TM) TUNEL assay), HNE-protein binding (by HNE-His ELISA) were higher in malignant than in normal cells, while glutathione content was higher in normal cells. These results indicate that HNE affects the growth of malignant mesenchymal cells more than normal and that this effect was mainly related to lower glutathione concentration and higher binding of HNE to the cellular proteins. We thus assume that HNE and GSH homeostasis play an important role in the growth regulation of normal and malignant mesenchymal cells.
Projekt / tema: 108-0532264-0048, 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.ingentaconnect.com/content/maney/rer/2007/00000012/F0020001/art00011
Broj citata:
Altmetric:
DOI: 10.1179/135100007X162194
URL cjelovitog teksta:
Google Scholar: Differential sensitivity to 4-hydroxynonenal for normal and malignant mesenchymal cells
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 6. Svi. 2008. u 15:52 sati



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