crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 341307

Časopis

Autori: Jaganjac, Morana; Poljak-Blaži, Marija; Žarković, Kamelija; Joerg Schaur, Rudolf; Žarković, Neven
Naslov: The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma
Izvornik: Cancer Letters (0304-3835) 260 (2008), 1-2; 180-186
Vrsta rada: članak
Ključne riječi: oxidative burst; granulocytes; Walker 256 carcinoma; anti-cancer effects; spontaneous tumour regression; sephadex; tumor-cell lysis; polymorphonuclear leukocytes; nonoxidative mechanisms; human-neutrophils; oxidative burst; cancer-patients; cytotoxicity; therapy; phagocytosis; mice
Sažetak:
We described before that oxidative burst of granulocytes is cytotoxic for melanoma B16F10 and for Walker 256 carcinoma (W256). Therefore, we assumed that granulocytes could also be important mechanism of the host defence against tumour. In current study we report massive granulocyte infiltration at the site of W256 transplanted in the hind limb of Sprague– Dawley associated with spontaneous tumour regression observed for 22/25 rats (87%). Peripheral blood granulocytes of these animals were highly cytotoxic for W256 cells cultured in vitro. After the tumour disappearance the inflammatory oxidative burst of the granulocytes ended. Distraction of granulocytes from the tumour by s.c. Sephadex injection decreased the incidence of the W256 regression to only 7/25 animals (30%). These results suggest that innate immunity based on immune competent granulocytes may be the cause of well known phenomenon of spontaneous regression of W256 carcinoma.
Projekt / tema: 198-0000000-3104, 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T54-4RM2F2P-5-1&_cdi=4992&_user=3875467&_orig=search&_coverDate=02%2F18%2F2008&_sk=997399998&view=c&wchp=dGLzVlz-zSkWb&md5=cdc36ced460486b175fb60d01747a811&ie=/sdarticle.pdf
Broj citata:
Altmetric:
DOI: 10.1016/j.canlet.2007.10.039
URL cjelovitog teksta:
Google Scholar: The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 7. Svi. 2008. u 09:11 sati



  Verzija za printanje   za tiskati


upomoc
foot_4