crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 341313

Časopis

Autori: Yelisyeyeva, Olha; Cherkas, Andriy; Žarković, Kamelija; Semen, Khrystyna; Kaminskyy, Danylo; Waeg, Georg; Žarković, Neven
Naslov: The distribution of 4-hydroxynonenal-modified proteins in gastric mucosa of duodenal peptic ulcer patients
Izvornik: Free Radical Research (1071-5762) 42 (2008), 3; 205-211
Vrsta rada: članak
Ključne riječi: lipid peroxidation; 4-hydroxynonenal; oxidative stress; helicobacter pylori; peptic ulcer; gastric mucosa; helicobacter-pylori infection; oxidative stress; lipid-peroxidation; nitric-oxide; colon-cancer; cells; eradication; glutathione; product; pathophysiology
Sažetak:
This study used monoclonal antibody specific for 4-hydroxynonenal (HNE)-histidine to evaluate immunohistochemical distribution of HNE-protein adducts in gastric mucosa biopsies of 52 peptic ulcer patients (all positive for H. pylori) and of 20 healthy volunteers (eight positive and 12 negative for H. pylori). HNE-modified proteins were present in glandular epithelium in all subjects, both patients with duodenal peptic ulcer and healthy subjects. Hence, the presence of HNE did not appear to be related to the presence of H. pylori. However, in patients with duodenal peptic ulcer accumulation of HNE-protein adducts was frequently observed also in nuclei, while in the control group such subcellular distribution of HNE was not observed at all. This study shows physiological presence of HNE in human gastric mucosa, but also suggests its role in pathology of gastric dysfunction in duodenal peptic ulcer patients manifested by accumulation of HNE-protein adducts in particular in nuclei of gastric glandular epithelium.
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
Broj citata:
Altmetric:
DOI: 10.1080/10715760801975743
URL cjelovitog teksta:
Google Scholar: The distribution of 4-hydroxynonenal-modified proteins in gastric mucosa of duodenal peptic ulcer patients
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 7. Svi. 2008. u 09:16 sati



  Verzija za printanje   za tiskati


upomoc
foot_4