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Pregled bibliografske jedinice broj: 342796

Zbornik radova

Autori: Borović Šunjić, Suzana; Štroser, Marina; Živković, Emilija; Žarković, Neven
Naslov: 4-hydroxynonenal enhances permeability of in vitro intestinal barrier model
Izvornik: Abstracts of the COST Meeting "Oxygen, stress and lipids"
Skup: COST Meeting "Oxygen, stress and lipids"
Mjesto i datum: Dubrovnik, Hrvatska, 26.-27.10.2007.
Ključne riječi: CaCo-2; differentiation; 4-hydroxynonenal; HNE; intestinal barrier; antioxidants; oxidative stress; gastrointestinal tract
Sažetak:
Human colon adenocarcinoma cell line CaCo-2 was shown to undergo spontaneous in vitro enterocytic differentiation leading to the formation of cell monolayer with several morphological an functional characteristics of mature enterocytes. Gastrointestinal tract is often exposed to harmful compounds originating from diet ; they can cause oxidative stress and intestinal dysfunction. Such dysfunction can make the intestinal barrier permeability greater for toxins, bacteries, harmful products of digestion, free radicals and second messangers of free radicals like 4-hydroxynonenal (HNE). HNE is one of major lipid peroxidation product, and because of its lipophilic caracter, it can be readily absorbed in the intestine or can accumulate in membranes causing phospholipid and protein damage. Cell monolayer was good developed after 15th day and represents intestinal barrier model. HNE impaired function of intestinal barrier model and caused increase in its permeability. With this study, we have shown that in vitro model of intestinal barrier could be used for oxidative stress research.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 7. Svi. 2008. u 16:11 sati



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