crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 346962

Časopis

Autori: Mastelić, Josip; Jerković, Igor; Blažević, Ivica; Poljak-Blaži, Marija; Borović, Suzana; Ivančić-Baće, Ivana; Smrečki, Vilko; Žarković, Neven; Brčić-Kostić, Krunoslav; Vikić-Topić, Dražen; Mueller, Norbert
Naslov: A comparative study on the antioxidant and biological activities of carvacrol, thymol and eugenol derivatives
Izvornik: Journal of agricultural and food chemistry (0021-8561) 56 (2008), 11; 3989-3996
Vrsta rada: članak
Ključne riječi: Carvacrol; eugenol; thymol; hydroxymethyl derivatives; diarylmethane derivative; antioxidant activity; antiproliferative activity; antimicrobial activity; antiyeast activity
Sažetak:
Four derivatives of thymol, carvacrol, and eugenol were synthesized: 4-(hydroxymethyl)-5-isopropyl- 2-methylphenol, 4, 4′ -methylenebis(5-isopropyl-2-methyl)phenol, 4-allyl-6-(hydroxymethyl)-2-methox- yphenol, and 4-(hydroxymethyl)-2-isopropyl-5-methylphenol. The obtained derivatives showed remarkably better antioxidative properties according to 1, 1-diphenyl-2-picrylhydrazyl assay (50% inhibitory concentrations ) 4– 156 µ ; g/mL) and Rancimat assay (protection factors ) 1.55– 5.84) when compared with parent compounds and values similar to or better than those of butylated hydroxy- toluene and vitamin C. At concentrations of 10 mM carvacrol derivatives had no toxic effect on viability of Escherichia coli K-12 (determined by minimum inhibitory concentrations). Other phenol derivatives showed reduced cytotoxic effect on E. coli K-12 at concentrations of 2– 5 mM on the basis of 50% lethal dose measurements. In comparison with the parent compounds, phenol derivatives showed reduced cytotoxic effect for Saccharomyces cerevisiae cells (determined by yeast colony reduction). On the other hand, the majority of synthesized compounds had dose-dependent antiproliferative effects on human uterine carcinoma cells (HeLa), which makes them potentially interesting for the adjuvant experimental cancer treatments. The 4, 4′ -methylenebis(5-isopropyl-2-methyl)phenol derivative of carvacrol showed lower inhibiting capacity also for the HeLa cells, which makes this particular derivative attractive as an effi cient antioxidant with negligible cytotoxic effects.
Projekt / tema: 011-0982929-1329, 108-0532264-0048, 108-0000000-0028, 098-0982464-2519, 098-0982929-2917, 098-0982913-2867, 119-1191196-1201
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2008/56/i11/abs/jf073272v.html
Broj citata:
Altmetric:
DOI: 10.1021/jf073272v
URL cjelovitog teksta:
Google Scholar: A comparative study on the antioxidant and biological activities of carvacrol, thymol and eugenol derivatives
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 9. Svi. 2008. u 12:59 sati



  Verzija za printanje   za tiskati


upomoc
foot_4