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Pregled bibliografske jedinice broj: 347736

Časopis

Autori: Gopčević, Aleksandar; Mazul-Sunko, Branka; Marout, Jasminka; Sekulić, Ante; Antoljak, Nataša; Širanović, Mladen; Ivanec, Željko; Margaritoni, Marko; Bekavac-Bešlin, Miroslav; Žarković, Neven
Naslov: Plasma Interleukin-8 as a potential predictor of mortality in adult patients with severe traumatic brain injury
Izvornik: Tohoku Journal of Experimental Medicine (0040-8727) 211 (2007), 4; 387-393
Vrsta rada: članak
Ključne riječi: traumatic brain injury; coma; mortality; inflammation; interleukin-8 (IL-8)
Sažetak:
Because of complex pathophysiology and severe consequences, traumatic brain injuries (TBI) are an important medical problem. Pathophysiology of TBI includes local and systemic stress response, in which interleukin-8 (IL-8) is considered as a key mediator of neuroinflammation. However, prognostic relevance of IL-8 measurement in adult patients with severe TBI is not certain. Therefore, IL-8 was determined in blood samples from central venous and jugular bulb catheter and in cerebrospinal fluid of twenty patients with isolated TBI at admission to Intensive Care Unit. None of the patients had history of stroke, dementia, autoimmune diseases, acute infection or medication with anti-inflammatory drugs. Ten patients died due to traumatic brain injury, while the other ten recovered well. While there was no significant difference of IL-8 levels in cerebrospinal fluid between survivors and nonsurvivors, central venous plasma level of IL-8 was significantly lower in survivors (71.00 +/- 14.17 pg/ml), than in nonsurvivors (111.26 +/- 16.9 pg/ml). Receiver Operating Characteristic (ROC) analysis revealed significant prognostic value for IL-8 in the blood as well as for the age of patients, Glasgow Coma Scale (GCS) and Acute Physiologic and Chronic Health Evaluation (APACHE II). These findings suggest that the central venous plasma values of IL-8 at admission might be an early predictive marker in patients with severe TBI, comparative to standard clinical prognostic markers such as APACHE II and GCS.
Projekt / tema: 108-0000000-0028, 098-0982464-2519, 006-0061245-0010, 108-0362979-0137
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.jstage.jst.go.jp/article/tjem/211/4/387/_pdf
URL cjelovitog teksta:
Google Scholar: Plasma Interleukin-8 as a potential predictor of mortality in adult patients with severe traumatic brain injury
Upisao u CROSBI: izuntar@pharma.hr (izuntar@pharma.hr), 9. Svi. 2008. u 16:34 sati



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