Hrvatska znanstvena Sekcija img
3 gif
 O projektu
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 350168


Autori: Duvnjak, Marko; Lerotić, Ivan; Baršić, Neven; Tomašić, Vedran; Virović-Jukić, Lucija, Velagić, Vedran
Naslov: Patgogenesis and management issues for non-alcocholic fatty liver disease
Izvornik: World Journal of Gastroenterology (1007-9327) 13 (2007), 34; 4539-4550
Vrsta rada: članak
Ključne riječi: Non-alcoholic fatty liver disease; Metabolic syndrome; Obesity; Insulin resistance; Liver fibrosis; NAFLD treatment
Non-alcoholic fatty liver disease, Metabolic syndrome, Obesity, Insulin resistance, Liver fibrosis, NAFLD treatment Sažetak: Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only relatively recently gained broader interest among physicians and scientists. Fatty liver has been documented in up to 10 to 15 percent of normal individuals and 70 to 80 percent of obese individuals. Although the pathophysiology of NAFLD is still subject to intensive research, several players and mechanisms have been suggested based on the substantial evidence. Excessive hepatocyte triglyceride accumulation resulting from insulin resistance is the first step in the proposed 'two hit' model of the pathogenesis of NAFLD. Oxidative stress resulting from mitochondrial fatty acids oxidation, NF-kappaB-dependent inflammatory cytokine expression and adipocytokines are all considered to be the potential factors causing second hits which lead to hepatocyte injury, inflammation and fibrosis. Although it was initially believed that NAFLD is a completely benign disorder, histologic follow-up studies have showed that fibrosis progression occurs in about a third of patients. A small number of patients with NAFLD eventually ends up with end-stage liver disease and even hepatocellular carcinoma. Although liver biopsy is currently the only way to confirm the NAFLD diagnosis and distinguish between fatty liver alone and NASH, no guidelines or firm recommendations can still be made as for when and in whom it is necessary. Increased physical activity, gradual weight reduction and in selected cases bariatric surgery remain the mainstay of NAFLD therapy. Studies with pharmacologic agents are showing promising results, but available data are still insufficient to make specific recommendations ; their use therefore remains highly individual.
Projekt / tema: 108-1080230-0143, 045-1080230-0516
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Patgogenesis and management issues for non-alcocholic fatty liver disease
Upisao u CROSBI: (, 12. Svi. 2008. u 09:54 sati

  Verzija za printanje   za tiskati