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Pregled bibliografske jedinice broj: 362101

Časopis

Autori: Poljak-Blaži, Marija; Jaganjac, Morana; Mustapić, Maja; Pivac, Nela; Muck-Šeler, Dorotea
Naslov: Acute immunomodulatory effects of iron polyisomaltosate in rats
Izvornik: Immunobiology (0171-2985) 214 (2009), 2; 121-128
Vrsta rada: članak
Ključne riječi: iron polyisomaltosate; oxidative burst of neutrophils; NF- B expression/activation; rats; serotonin
Sažetak:
Anti-anaemic drug ferric-sorbitol citrate showed immunomodulatory effects, activating NF- B in peritoneal macrophages, which consequently secrete TNF- . TNF- activates NF- B in the spleen cells. Aim of the study was to investigate the effect of iron polyisomaltosate, an iron (Fe3+) compound, on serum iron, interleukin-6 (IL-6) and serotonin (5-HT) concentration, neutrophil activity, and NF- B activation in peritoneal macrophages and spleen cells in rats. Female Wistar rats were injected i.p. with 7.5 mg iron/kg of iron polyisomaltosate 1.5, 3, 6, 24 and 48h before sacrifice. Serum iron, 5-HT and IL-6 concentration was determined by colorimetric, spectrofluorimetric and ELISA methods, neutrophil activity by a chemiluminescence assay, and NF- B expression/activation by a Dot Blot method. Iron polyisomaltosate significantly increased serum iron and 5-HT concentrations during the first 6h, IL-6 levels 3h and 6h, and diminished respiratory burst of granulocytes 1.5h after the injection. Iron polyisomaltosate stimulated activation of p65, p50 and RelB subunits of NF- B in the peritoneal macrophages after 6h, and RelB subunit was additionally increased after 24 and 48h. In the spleen cells iron polyisomaltosate stimulated p65 subunit after 48h and RelB subunit after 24h. The results showed time-dependent immunomodulatory effects of iron polyisomaltosate. These effects might be achieved via induction of the intracellular signalling for NF- B activation in peritoneal macrophages and later in spleen cells, together with increase of serum 5-HT, and IL-6 but diminished respiratory burst of granulocytes. Iron polyisomaltosate presumably activated reactive oxygen species resulting in the stimulation of the acute phase reactants in the liver.
Projekt / tema: 098-0982522-2457, 098-0982522-2455, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7GW1-4T9BXD7-4&_user=4761862&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050661&_version=1&_urlVersion=0&_userid=4761862&md5=465da0f22caab0972e28b4bcb8920f70
Broj citata:
Altmetric:
DOI: doi:10.1016/j.imbio.2008.07.005
URL cjelovitog teksta:
Google Scholar: Acute immunomodulatory effects of iron polyisomaltosate in rats
Upisao u CROSBI: seler@irb.hr (seler@irb.hr), 11. Srp. 2008. u 13:24 sati



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