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Pregled bibliografske jedinice broj: 363189

Časopis

Autori: Ćaleta, Irena; Grdiša, Mira; Mrvoš-Sermek, Draginja; Cetina, Mario; Tralić-Kulenović, Vesna; Pavelić, Krešimir; Karminski-Zamola, Grace
Naslov: Synthesis, crystal structure and antiproliferative evaluation of some new substituted benzothiasoles and styrlbenzothiazoles
Izvornik: Il Farmaco (Pavia) (0014-827X) 59 (2004), 4; 297-305
Vrsta rada: članak
Ključne riječi: aminodibenzothiazoles; aminostyrylbenzothiazoles; X-ray crystal structure analysis; antitumor activity; cell lines
Sažetak:
The multistep synthesis of a series of new substituted-benzothiazoles as hydrochloride or quaternary salts is described. 6-Amidino substituted 2-aminobenzothiazoles (5, 6), N-methyl-2-(4-cyanostyryl)benzothiazolium iodide (8), cyano-substituted-2-styrylbenzothiazoles (9-11) and amidino and bis-amidino-substituted 2-styrylbenzothiazoles (12-17) were prepared. The crystal structure of amidino derivative (6) was determined by single crystal X-ray analysis. All new prepared compounds were tested on the cytostatic activities against malignant cell lines: (SW620, colon carcinoma ; Hep2, laryngeal carcinoma ; HBL, melanoma ; HeLa, cervical carcinoma and WI38, human normal fibroblasts). The compounds exerted a different inhibitory effect, depended on concentration and type of the cells. The best inhibitory effect was achieved with compounds (12-15), with slight differences among them. All of them inhibited the growth of examined tumor cell lines and also normal fibroblasts. Other examined compounds exhibited a moderate inhibitory effect, depending on type of the cells. Majority of them inhibited the growth of HeLa cells and WI38.
Projekt / tema: 0098093, 0125003, 0125005
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VJ8-4BYN5PF-5-S&_cdi=6088&_user=3875467&_orig=browse&_coverDate=04%2F30%2F2004&_sk=999409995&view=c&wchp=dGLbVtz-zSkWb&md5=2b52ca388a3ce6f1673552bfde6f6ada&ie=/sdarticle.pdf
Broj citata:
Altmetric:
DOI: 10.1016/j.farmac.2004.01.008
URL cjelovitog teksta:
Google Scholar: Synthesis, crystal structure and antiproliferative evaluation of some new substituted benzothiasoles and styrlbenzothiazoles
Upisao u CROSBI: grdisa@irb.hr (grdisa@irb.hr), 31. Srp. 2008. u 13:45 sati



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