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Autori: Milin Čedomila; Tota Marin; Domitrović Robert
Naslov: Utjecaj prehrane preopterećene željezom i obogaćene maslinovim i kukuruznim uljem na koncentraciju tokoferola i retinola kod miševa
( INFLUENCE OF HIGH DIETARY IRON ON TOCOPHEROL AND RETINOL CONCENTRATION IN MICE FED OLIVE- AND CORN-OIL ENRICHED DIET )
Izvornik: IFCC - Worldlab 2008, Abstracts CD ROM
Skup: IFCC-WorldLab Fortaleza 2008 20th International Congress of Clinical Chemistry and Laboratory Medicine XXXV Brazilian Congress of Clinical Analysis VIII Brazilian Congress of Clinical Citology
Mjesto i datum: Fortaleza, Brazil, 28.09-02.10.2008
Ključne riječi: željezo; maslinovo ulje; tokoferol; retinol
( iron; olive oil; tocopherol; retinol )
Sažetak:
Background. Iron is an essential mineral for growth and development of most organisms but can also play a catalitic role in initiation of free radical reactions. These free radicals potentially damage cellular lipids, proteins and carbohydrates. High content of dietary iron may result with increased lipid peroxidation especially in diet with higher proportion of polyunsaturated fatty acids (PUFAs) but little is known about these interactions. Therefore, the aim of this study was to determine the effect of a high dietary iron on a-tocopherol and retinol status in mice fed olive oil and corn oil supplemented diets. Methods. Male Balb/c mice were divided in five groups and fed for three weeks. The control group was fed a standard rodent diet and the other groups were supplemented with either olive- or con-oil with adequate Fe or excess Fe. Fe levels in liver tissue was determined by inductively coupled plasma spectrometry, fatty acid analysis was done by gas chromatography and vitamin levels were mesured by high-performance liquid chromatography. Results. Both dietary oils and iron increased the liver Fe uptake and changed the liver fatty acid composition. Additionally, high-iron diet induced oxidative stress in mice liver. Liver retinol and tocopherol stores increased with iron supplementation in the olive oil-enriched diet, with a simultaneous decrease in serum. The results suggest that the influx of tocopherol and retinol from serum to the liver is induced by high dietary iron. This redistribution appears to be stronger for retinol than for tocopherol and is also higher in mice fed olive oil than in mice fed corn oil, suggesting that the composition of dietary lipids is important in the treatment of high-iron tissue conditions. Conclusions. The results of this study suggest that the increase of hepatic tocopherol and retinol levels in the olive oil-based diet is a dietary-dependent responsive mechanism that probably is not primarily related to an increase risk of oxidative damage induced by high-iron intake.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0621341-0061
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
Upisao u CROSBI: mtota@medri.hr (mtota@medri.hr), 7. Lis. 2008. u 15:02 sati



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