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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 369048

Časopis

Autori: Džimbeg, Gabrijela; Zorc, Branka; Kralj, Marijeta; Ester, Katja; Pavelić, Krešimir; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Naslov: The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations
Izvornik: European journal of medicinal chemistry (0223-5234) 43 (2008), 6; 1180-1187
Vrsta rada: članak
Ključne riječi: Antiviral agents; Antitumoral agents; Primaquine; Biologically active compounds; Urea
Sažetak:
The novel urea primaquine derivatives 3a– i were prepared by aminolysis of benzotriazolide 2 with the corresponding amine in the presence or absence of triethylamine. Compound 2 was prepared by acylation of primaquine with 1-benzotriazole carboxylic acid chloride. Among all compounds evaluated, the pyridine derivative 3h exhibited the best cytostatic activities against colon carcinoma, human T-lymphocyte and murine leukemia. However, this compound showed also rather marked cytotoxicity towards human normal fibroblasts. The highest selectivity in the inhibitory effects on human malignant tumor cell lines vs. normal fibroblasts was found for ureas 3c, 3d and 3g. Results of broad antiviral evaluation showed that pyridine and phenethyl derivatives of urea 3h and 3g exhibited some selective inhibition against cytomegalovirus.
Projekt / tema: 006-0000000-3216, 098-0982464-2514, 098-0982464-2393, 125-0982464-2922
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Farmacija
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VKY-4PNM44J-1-1&_cdi=6135&_user=3875467&_orig=search&_coverDate=06%2F30%2F2008&_sk=999569993&view=c&wchp=dGLbVzW-zSkzk&md5=8534f82392e7ac015dd07993d47e6f01&ie=/sdarticle.pdf
Broj citata:
Altmetric:
DOI: 10.1016/j.ejmech.2007.09.001
URL cjelovitog teksta:
Google Scholar: The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations
Upisao u CROSBI: bzorc@pharma.hr (bzorc@pharma.hr), 22. Lis. 2008. u 16:01 sati



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