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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 369081

Časopis

Autori: Perković, Ivana; Butula, Ivan; Zorc, Branka; Hock, Karlo; Kraljević Pavelić, Sandra; Pavelić, Krešimir; De Clercq, Erik; Balzarini, Jan; Mintas, Mladen
Naslov: Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations
( Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations )
Izvornik: Chemical biology & drug design (1747-0277) 71 (2008), 6; 546-553
Vrsta rada: članak
Ključne riječi: antiviral activity; cytostatic activity; human tumor cell lines; hydroxyureas
( antiviral activity; cytostatic activity; human tumor cell lines; hydroxyureas )
Sažetak:
The novel hydroxyurea derivatives of l- and d-amino acid amides 5a– l were prepared by aminolysis of N-(1-benzotriazolecarbonyl)-amino acid amides 4a– f with O-benzylhydroxylamine and N-methylhydroxylamine and evaluated for their antiviral and cytostatic activity against malignant tumor cell lines and normal human fibroblasts. Compounds 5a, 5c, 5e and 5k showed the highest antiproliferative effects against all tumor cell lines tested. The strongest non-specific cytostatic activities against HeLa cells were affected by compounds 5a, 5c, 5e and 5k on MCF-7 cells by 5c, 5e and 5k and MIA PACa-2 cells by 5c and 5k. Differential effects at micromolar concentrations were observed for compounds 5a, 5c, 5e, 5k and 5l in Hep G2 cells, for compounds 5c, 5e, 5k and 5l in PC-3 cells and for compounds 5e, 5k and 5l in SW 620 cells.
Projekt / tema: 098-0982464-2393, 125-0982464-2922, 006-0000000-3216
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Farmacija
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2008.00660.x/abstract
http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2008.00660.x/pdf
Broj citata:
Altmetric:
DOI: 10.1111/j.1747-0285.2008.00660.x
URL cjelovitog teksta:
Google Scholar: Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations
Upisao u CROSBI: bzorc@pharma.hr (bzorc@pharma.hr), 23. Lis. 2008. u 10:13 sati



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