The role of the cerebrospinal fluid biomarkers in a tertiary memory clinic: our 4-year experience (CROSBI ID 543183)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Boban, Marina ; Grbić, Kristina ; Mladinov, Mihovil ; Hof, Patrick ; Suessmair, Christine ; Ackl, Nibal ; Bader, Benedict ; Danek, Adrian ; Šimić, Goran
engleski
The role of the cerebrospinal fluid biomarkers in a tertiary memory clinic: our 4-year experience
Background: Alzheimer's disease (AD) is the most prevalent type of dementia. Although diagnostic markers for AD have been continuously improving, they still do not guarantee a definite diagnosis. However, it is safe to say that known biological markers from cerebrospinal fluid (CSF) can differentiate AD from other primary causes of dementia with high reliability and validity. As such, they were recently, together with structural and functional neuroimaging and genetic testing, included as an ancillary method in the clinical diagnostic criteria for AD. Objective: To assess the usability of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau-181) and beta-amyloid in a mixed population of patients with suspected dementia referred to a tertiary memory clinic. Patients and methods: Fifty-four consecutive patients with various primary causes of the dementia syndrome were included in the study. A retrospective diagnosis was established using the consensus criteria without prior knowledge of the CSF results. Lumbar puncture was performed as a part of the routine clinical workup. Levels of t-tau, p-tau-181 and beta-amyloid in CSF were measured using commercially available ELISA kits from Innogenetics, Ghent, Belgium and Biosource International, Camarillo, CA, USA. Results: Except for beta-amyloid, the overall sensitivity of the other two markers for diagnosis of AD was in range from 77 to 92%.
aging ; Alzheimer's disease ; cerebrospinal fluid ; cognition ; dementia ; diagnosis ; mild cognitive impairment ; tau proteins
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Podaci o prilogu
80-80.
2008.
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objavljeno
Podaci o matičnoj publikaciji
Neurologia Croatica. Supplement
Šimić, Goran ; Mimica, Ninoslav ; Petravić, Damir
Zagreb: Denona
1331-5196
Podaci o skupu
4th Croatian Congress on Alzheimer's disease with international participation
poster
08.10.2008-11.10.2008
Rovinj, Hrvatska