crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 37175

Časopis

Autori: Pavelić, Krešimir; Kapitanović, Sanja; Radošević, Senka; Bura, Miljenko; Seiwerth, Sven; Pavelić, Ljubomir; Unušič, Josip; Spaventi, Radan
Naslov: Increased activity of nm23-H1 gene in squamous cell carcinoma of the head and neck is associated with advanced disease and poor prognosis
Izvornik: Journal of molecular medicine (1107-3756) 78 (2000), 2; 111-118
Vrsta rada: članak
Ključne riječi: head and neck cancer; nm23-H1 gene
Sažetak:
The present study was undertaken to determine whether nm23-H1 gene is expressed in squamous cell carcinoma of the head and neck (SCCHN), as well as to establish whether or not the alterations in the level of nm23-H1 protein or mRNA occur in cells as they progress to a more malignant phenotype. Fifthy four (45%) of the 120 SCCHN studied stained positively for nm23-H1 protein. Protein expression was significantly higher in higher stages of disease. Expression of nm23-H1 was significantly higher in cancer tissues in comparison to normal, adjacent tissue, dysplasia or carcinoma in situ. The nm23-H1 score increased with progression of synchronous lesions from dysplasia to carcinoma in situ and finally to carcinoma (p<0.05). Northern blot analyses of tissues with different clinicopathological characteristics also revealed differences of nm23-H1 mRNA expression. When levels of nm23-H1 mRNA was compared with tumor stage, intensity of expression increased in stages 3 and 4 in comparison to stage 1 and 2 (p<0.01). Malignant tumors had increased level of mRNA nm23-H1 expression than normal or premalignant tissues. Nm23-H1 negative patients survived significantly longer than nm23-H1 positive ones (p<0.05). In order to evaluate whether a relationship between nm23-H1 gene expression and cell growth rate exists in tumor cells, in each tumor, the mRNA level was compared to proliferative activity. The nm23-H1 gene expression levels were directly related to the [3H]-thymidine labeling index in tumor cells (R=0.6681). Our results strongly indicate that nm23-H1 gene is involved in progression of SCCHN. Together with results obtained on lung cancer, our observation suggests that increased expression of nm23-H1 in cancers of the upper aerodigestive tract may have different implications than elsewhere in the body.
Projekt / tema: 101751, 00981104, 108071
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Increased activity of nm23-H1 gene in squamous cell carcinoma of the head and neck is associated with advanced disease and poor prognosis



  Verzija za printanje   za tiskati


upomoc
foot_4