crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 372329

Časopis

Autori: Pešić, Dijana; Ozimec Landek, Ivana; Čikoš, Ana; Metelko, Biserka; Gabelica, Vesna; Stanić, Barbara; Merćep, Mladen; Mesić, Milan
Naslov: Synthesis of 2-formyl-1-aza-dibenzo[e, h]azulenes
( Synthesis of 2-formyl-1-aza-dibenzo[e, h]azulenes )
Izvornik: Journal of Heterocyclic Chemistry (0022-152X) 44 (2007), 5; 1129-1133
Vrsta rada: članak
Ključne riječi: dibenzoazulenes ; anti-inflammatory compounds ; TNF-alpha
( dibenzoazulenes ; anti-inflammatory compounds ; TNF-alpha )
Sažetak:
Synthesis of a novel heterocyclic class of compounds, 1-aza-dibenzo(e, h)azulenes derived from dibenzo(b, f)oxepin, its 8-chloro analogue and dibenzo(b, f)thiepin, respectively, is described. Aldol condensation of the starting ketones 4a-c with (dimethyl-hydrazono)-acetaldehyde affords dydrazonoethylidene derivatives 5a-c, which on reduction with sodium dithionite and subsequent cyclization provide target tetracyclic 1-aza-dibenzo(e, h)azulenes 6a-c. Regiospecific formylation of 6a-c with Vilsmeier reagent leads to 2-formyl derivatives 7a-c. A series of derivatives 6a-c and 7a-c was tested for antiinflammatory activity as potential inhibitors of tumor necrosis factor alpha (TNF-a) production in vitro.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Synthesis of 2-formyl-1-aza-dibenzo[e, h]azulenes
Upisao u CROSBI: mmercep@mef.hr (mmercep@mef.hr), 19. Stu. 2008. u 18:40 sati



  Verzija za printanje   za tiskati


upomoc
foot_4