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Pregled bibliografske jedinice broj: 376497

Časopis

Autori: Rajić, Zrinka; Butula, Ivan; Zorc, Branka; Kraljević Pavelić, Sandra; Hock, Karlo; Pavelić, Krešimir; Naesens, Lieve; De Clercq, Erik; Balzarini, Jan; Przyborowska, Monika; Ossowski, Tadeusz; Mintas, Mladen
Naslov: Cytostatic and Antiviral Activity Evaluations of Hydroxamic Derivatives of Some Nonsteroidal Anti-Inflammatory Drugs
Izvornik: Chemical Biology and Drug Design (1747-0277) 73 (2009), 3; 328-338
Vrsta rada: članak
Ključne riječi: NSAID hydroxamic acids; antitumor agents; tumor cells: effectors of apoptosis
Sažetak:
NSAID pharmacophores are interesting in designing potential anticancer drugs. Indeed, numerous experimental, epidemiologic, and clinical studies suggest that NSAIDs are promising anticancer drugs. Herein, NSAID hydroxamic acids 3a-i were prepared by a new synthetic procedure and evaluated for their antiviral and cytostatic activity against malignant tumor cell lines and normal human fibroblasts (WI38). Antiviral activity evaluation results indicated that 3f had only a minor activity against the influenza virus A/H1N1 subtype with a selectivity index of 7– 10. On the other hand, the results of the in vitro cytostatic activity evaluations revealed that the majority of NSAID hydroxamic acid derivatives 3a-i exhibited a strong non-specific antiproliferative effect at the highest concentration (100 µ ; ; ; M) on the tested cell line panel. Only compounds 3b, 3e and 3i exerted a differential dose-dependent inhibitory activity against the growth of HeLa cells (p < 0.05) at concentration 10 µ ; ; ; M. Among those three compounds, only compound 3b showed a selective cytostatic effect on HeLa in comparison to normal fibroblasts.
Projekt / tema: 006-0000000-3216, 125-0982464-2922, 098-0982464-2393
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL cjelovitog teksta:
Google Scholar: Cytostatic and Antiviral Activity Evaluations of Hydroxamic Derivatives of Some Nonsteroidal Anti-Inflammatory Drugs
Upisao u CROSBI: mmintas@fkit.hr (mmintas@fkit.hr), 22. Pro. 2008. u 12:17 sati



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