crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 377767

Zbornik radova

Autori: Čikeš Čulić, Vedrana; Rešić, Jasminka; Tomasović, Maja; Zemunik, Tatijana; Markotić, Anita
Naslov: Glycosphingolipid expression in neural tissues of three rat strains
Izvornik: Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation : HDBMB 2008 : book of abstracts / Strelec, Ivica ; Glavaš-Obrovac, Ljubica (ur.). - Osijek : Hrvatsko društvo za biokemiju i molekularnu biologiju , 2008. 78-78 (ISBN: 978-953-95551-2-0).
Skup: Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation
Mjesto i datum: Osijek, Hrvatska, 17-20.09.2008.
Ključne riječi: glycosphingolipid; neural tissues; rat strains
Sažetak:
Many neurological disorders and injuries such as Parkinson's disease, multiple sclerosis, stroke, traumatic injury to CNS etc. have movement abnormalities as major symptom. Numerous animal models of neurological disease and injury exist, especially in rats, and most common used strains are Lewis, Wistar and Sprague-Dawley (SD). These three strains show different neurological behaviour. Glycosphingolipids (GSLs), both neutral and gangliosides are, according to their role, differently distributed in neural tissues and synaptic mechanisms. Therefore, comparison of GSL expression in neural tissues of three rat strains was performed. The aim was to identify GSL profile in brain, cerebellum and brain stem of each rat strain which could be responsible for different neurological behaviour. Three different male, age-matched rat strains were used: Lewis, Wistar and Sprague-Dawley. GSLs were isolated from animal tissues by standard procedure. Distribution of GSLs in brain, cerebellum and brain stem of each group of animals were analyzed by orcinol staining. GSLs were abundant in the brain of Lewis rats compared to lower expression in Wistar brain and traces of GSLs in SD brain. Cerebellum and brain stem of Wistar rats showed the highest GSL expression. Lewis cerebellum and brain stem showed lower expression of gangliosides and higher of neutral GSLs compared to the same Wistar tissues. SD cerebellum and brain stem showed traces of gangliosides and abundant expression of neutral GSLs. We define GSL profile in brain, cerebellum and brain stem of f Wistar, Lewis and SD rats which could be starting point for choice and defining neurochemical experiments with those strains.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 216-1080315-0293, 216-2160133-0066
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: amarkoti@mefst.hr (amarkoti@mefst.hr), 8. Sij. 2009. u 15:33 sati



  Verzija za printanje   za tiskati


upomoc
foot_4