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izvor podataka: crosbi

The effect of a single dose of fumonisin B-1 on rat kidney (CROSBI ID 146755)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Peraica, Maja ; Ljubanović, Danica ; Želježić, Davor ; Domijan, Ana-Marija The effect of a single dose of fumonisin B-1 on rat kidney // Croatica chemica acta, 81 (2008), 1; 119-124

Podaci o odgovornosti

Peraica, Maja ; Ljubanović, Danica ; Želježić, Davor ; Domijan, Ana-Marija

engleski

The effect of a single dose of fumonisin B-1 on rat kidney

It is known that exposure to mycotoxin fumonisin B1 (FB1) causes apoptosis and increases lipid peroxidation in the kidney of experimental animals. In this study, adult male Wistar rats were given a single dose (5, 50, 500 ug/kg b.w.) by gavage and sacrificed four, 24 and 48 hours after dosing. The parameters of oxidative stress, concentration of sphingolipids, DNA lesions and histopathological changes were checked in the kidney of treated and control animals. The metabolism of sphingolipids was significantly affected with the lowest FB1 dose (Sa/So: 2.53 0.52 vs. control 0.62 0.10), while even the highest dose did not change the parameters of oxidative stress. DNA lesions measured as comet tail length (range 13.6 0.41  m to 19.83 1.43  m) and tail intensity (0.60 0.16 to 2.74 0.17) were FB1 dose- and time- dependent. Apoptotic cells and mitotic figures were found in the cortical and outer stripe of the medullar part of the kidney.

mycotoxin; comet assay; glutathione; oxidative stress; histopathology; sphingolipids

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Podaci o izdanju

81 (1)

2008.

119-124

objavljeno

0011-1643

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost