engleski

Effect of extracellular NADH on human tumor cell proliferation

We investigated the antiproliferative effects of extracellular mcotinamide adenine dinucleotide against human malignant CaCo-2 (colon carcinoma), Hep-2 (laringeal carcinoma) cell lines, as well as against murine fibrosarcoma and normal human embrional fibroblast (HEF). NADH was very potent in the growth inhibition of murine fibrosarcoma and human Hep-2 cells, regardless of the dose applied. During the observed period (4 or 5 days) only one dose of NADH was sufficient in reducing the growth rate for up to 92%. It had no effect on the growth of other cell lines tested. The identification of DNA-fragmentation and p53 and Ki-67 genes expression suggest that the mechanism of NADH action is different from disregulation of genes considered as checkpoints in cell cycle.

NADH; tumor; proliferation

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