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Pregled bibliografske jedinice broj: 37917

Časopis

Autori: Slade, Neda; Štorga-Tomić, Danijela; Birkmayer, George D.; Pavelić, Krešimir; Pavelić, Jasminka
Naslov: Effect of extracellular NADH on human tumor cell proliferation
Izvornik: Anticancer research (0250-7005) 19 (1999); 5355-5360
Vrsta rada: članak
Ključne riječi: NADH; tumor; proliferation
Sažetak:
We investigated the antiproliferative effects of extracellular mcotinamide adenine dinucleotide against human malignant CaCo-2 (colon carcinoma), Hep-2 (laringeal carcinoma) cell lines, as well as against murine fibrosarcoma and normal human embrional fibroblast (HEF). NADH was very potent in the growth inhibition of murine fibrosarcoma and human Hep-2 cells, regardless of the dose applied. During the observed period (4 or 5 days) only one dose of NADH was sufficient in reducing the growth rate for up to 92%. It had no effect on the growth of other cell lines tested. The identification of DNA-fragmentation and p53 and Ki-67 genes expression suggest that the mechanism of NADH action is different from disregulation of genes considered as checkpoints in cell cycle.
Projekt / tema: 00981103, 00981104
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Effect of extracellular NADH on human tumor cell proliferation



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