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Pregled bibliografske jedinice broj: 38046

Časopis

Autori: Dabelić, Nina; Mateša, Neven; Gall-Trošelj, Koraljka; Krušlin, Božo; Pavelić, Jasminka; Pavelić, Krešimir; Kusić, Zvonko
Naslov: Medullary thyroid carcinoma
Izvornik: Acta Clinica Croatica (0353-9466) 38 (1999), 4; 227-239
Vrsta rada: članak
Ključne riječi: medullary thyroid carcinoma; sporadic; familial; multiple endocrine neoplasia type 2 syndrome; calcitonin specific tumor marker; ret proto-oncogene
Sažetak:
Medullary thyroid carcinoma (MTC) is an uncommon thyroid tumor accounting for only 3%-5% of all thyroid malignancies. Nevertheless, it has attracted a great deal of interest for its distinctive biochemical and genetic features and unique clinical associations, with a predilection for early diagnosis and an appropriate surgical approach. In this paper, we review these features, including the four distinct clinical forms of MTC: sporadic MTC, familial MTC (FMTC), and multiple endocrine neoplasia 2A and 2B syndromes. We also review the role of serum calcitonin levels as a specific tumor marker in this carcinoma. Special emphasis is put on the recent key advances that have clarified the genetic basis of MTC and now hold tremendous promise for improving the diagnosis and treatment of this cancer. In addition, we give an overview of our clinical experience with a total of 33 patients we have encountered during a 20-year period at the Department of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital.
Projekt / tema: 00981103, 00981104, 134001
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL cjelovitog teksta:
Google Scholar: Medullary thyroid carcinoma



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