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Pregled bibliografske jedinice broj: 381227

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Autori: Davosir Klarić, Željka; Hafner, Anita; Tomić, Siniša; Zubčić, Snježana; Filipović-Grčić, Jelena
Naslov: Spray-dried chitosan microspheres with lecithin nanocores as cyclosporin A delivery system
( Spray-dried chitosan microspheres with lecithin nanocores as cyclosporin A delivery system )
Izvornik: Farmacevtski vestnik / Mrhar, Aleš ; Baumgartner, Saša (ur.). - Ljubljana : Slovenian Pharmaceutical Society , 2008. 115-116.
ISSN: 0014-8229
Skup: 7th Central Europen Symposium on Pharmaceutical Technology and Biodekivery Systems
Mjesto i datum: Ljubljana, Slovenija, 18-20.09.2008.
Ključne riječi: Spray-driying; Chitosan; Microspheres; Lecithin; Cyclosporin A
( Spray-driying; Chitosan; Microspheres; Lecithin; Cyclosporin A )
Sažetak:
Cyclosporin is a highly lipophilic neutral cyclic peptide consisting of 11 amino acids. Its low water solubility present a serious problem causing undesirable biopharmaceutical properties, such as erratic bioavailability from oral and topical routes (1). To overcome this problem bioadhesive drug delivery system like chitosan microspheres could be used (2). Chitosan, a polycationic biopolymer is well known for its several favorable biological properties such as biodegradability, nontoxicity and biocompatibility (2). In this study spray-drying method was used for preparing chitosan microspheres with lecithin nanocores as delivery system for cyclosporin A (CyA). The swelling properties of the microspheres and in vitro CyA release were investigated. A new method for the preparation of spray-dried CyA-loaded hydrophilic microspheres was developed. Incorporation of lecithin nanocores into hydrophylic chitosan matrix resulted in improved CyA entrapment, swelling ability and control over CyA release.
Rad je indeksiran u
bazama podataka:
Scopus
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 006-0061117-1244
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Farmacija
Upisao u CROSBI: jfilipov@pharma.hr (jfilipov@pharma.hr), 6. Vel. 2009. u 13:21 sati



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